excision repair


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ex·ci·sion re·pair

the use of a complementary DNA strand as a template to replace a damaged segment of DNA.

excision repair

Correction of DNA damage by the removal of the damaged length of single strand by one of a number of enzymes capable of recognizing damaged nucleotides, and resynthesizing the correct nucleotide sequence complementary to the normal strand. The repair is catalyzed by DNA polymerase I and DNA ligase.

excision repair

the removal of damaged polynucleotide segments from DNA (e.g. THYMINE DIMERS produced by ultraviolet light) and replacement with a correct segment using DNA POLYMERASE and DNA LIGASE.
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References in periodicals archive ?
In marked contrast, NAC treatment did not rescue the nucleotide excision repair mutants [[XPA.sup.-/] and [XPG.sup.-/] (Xeroderma pigmentosum complementation group G)l (Table 4).
A novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants
This damage is usually repaired by a process called nucleotide excision repair, which cuts out and replaces sections of damaged DNA.
Hitting cancer cells with chemo at right time may boost survival chances
Furthermore, building on theefforts of PharmaMar to understand the mechanism of action of the drug candidates and products in the pipeline, data will show efficacy of Yondelis and PM01183 in cells derived from patients that lack specific factors of the DNA repair mechanism NER (nucleotide excision repair) (Abstract #57, Nov.
Spain : PharmaMar results for antitumoral compounds and their mechanism of action at EORTC-NCIAACR emphasize an innovative pipeline of targeted therapies
Apurinic/apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1, APEX1, here referred to as APE1) has multifunctions as a base excision repair enzyme and as a redox coactivator of a number of important transcription factors.
Human AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis risk
Nucleotide excision repair pathway involved in the DNA repair processes plays an important role in the efficacy of chemotherapy.
The association of XPG and MMS19L polymorphisms response to chemotherapy in osteosarcoma
1992) and incision steps of nucleotide excision repair (NER), even at low concentrations (Hartwig 1998; Hartwig et al.
Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire
Bulky DNA adducts by cisplatin are mainly repaired by the mechanism of nucleotide excision repair pathway (NER).2,3 During the NER pathway, the proteins of the excision repair cross complementing 1 (ERCC1) and ribonucleotide reductase subunit M1(RRM1) play an important role in this pathway.
Expression levels of ERCC1 and RRM1 mRNA and clinical outcome of advanced non-small cell lung cancer
Millikan of the University of North Carolina at Chapel Hill and his colleagues document findings suggesting that specific combinations of polymorphisms on certain nucleotide excision repair (NER) genes may modify the risk of breast cancer in black women who smoke.
Polymorphisms modify breast cancer risk in smokers
It is well known that there are five main DNA repair pathways with more than 130 genes, of which the nucleotide excision repair (NER) pathway plays a crucial DNA repair mechanism by removing various DNA lesions caused by UV radiation and some chemical agents, such as bulky adducts, cross links, oxidative DNA and alkylating damage and thymidine dimers.6-8 It is reported that xeroderma pigmentosum (XP) complementation groups in human, XPA to XPG, represent the ratelimiting proteins in the NER pathway.
Effect of Xeroderma pigmentosum complementation group F polymorphisms and H.pylori infection
In the present study we used individual-level exposure data and biologic samples to investigate the effects of As exposure on nucleotide excision repair in two study populations, focusing on the excision repair cross-complement 1 (ERCC1) component.
Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic
Defective nucleotide excision repair in XPC mutant mice and its association with cancer predisposition.
XPG is a novel biomarker of clinical outcome in advanced non-small-cell lung cancer
More than 15 ns-cSNPs were detected in five genes: insulin-like growth factor receptor 2 (IGF2R) with 21 ns-cSNPs, REV3-like, catalytic subunit of DNA polymerase zeta (REV3L) with 21 ns-cSNPs, protein kinase, DNA-activated, catalytic polypeptide (PRKDC) with 20 ns-cSNPs, exonuclease 1 (EXO1) with 17 ns-cSNPs, and the excision repair cross-complementing rodent repair deficiency, complementation group 6 (ERCC6) with 16 ns-cSNPs.
An overview of the environmental genome project

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