In marked contrast, NAC treatment did not rescue the nucleotide
excision repair mutants [[XPA.sup.-/] and [XPG.sup.-/] (Xeroderma pigmentosum complementation group G)l (Table 4).
This damage is usually repaired by a process called nucleotide
excision repair, which cuts out and replaces sections of damaged DNA.
Apurinic/apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1, APEX1, here referred to as APE1) has multifunctions as a base
excision repair enzyme and as a redox coactivator of a number of important transcription factors.
Nucleotide
excision repair pathway involved in the DNA repair processes plays an important role in the efficacy of chemotherapy.
1992) and incision steps of nucleotide
excision repair (NER), even at low concentrations (Hartwig 1998; Hartwig et al.
Bulky DNA adducts by cisplatin are mainly repaired by the mechanism of nucleotide
excision repair pathway (NER).2,3 During the NER pathway, the proteins of the
excision repair cross complementing 1 (ERCC1) and ribonucleotide reductase subunit M1(RRM1) play an important role in this pathway.
Millikan of the University of North Carolina at Chapel Hill and his colleagues document findings suggesting that specific combinations of polymorphisms on certain nucleotide
excision repair (NER) genes may modify the risk of breast cancer in black women who smoke.
It is well known that there are five main DNA repair pathways with more than 130 genes, of which the nucleotide
excision repair (NER) pathway plays a crucial DNA repair mechanism by removing various DNA lesions caused by UV radiation and some chemical agents, such as bulky adducts, cross links, oxidative DNA and alkylating damage and thymidine dimers.6-8 It is reported that xeroderma pigmentosum (XP) complementation groups in human, XPA to XPG, represent the ratelimiting proteins in the NER pathway.
In the present study we used individual-level exposure data and biologic samples to investigate the effects of As exposure on nucleotide
excision repair in two study populations, focusing on the
excision repair cross-complement 1 (ERCC1) component.
Defective nucleotide
excision repair in XPC mutant mice and its association with cancer predisposition.
More than 15 ns-cSNPs were detected in five genes: insulin-like growth factor receptor 2 (IGF2R) with 21 ns-cSNPs, REV3-like, catalytic subunit of DNA polymerase zeta (REV3L) with 21 ns-cSNPs, protein kinase, DNA-activated, catalytic polypeptide (PRKDC) with 20 ns-cSNPs, exonuclease 1 (EXO1) with 17 ns-cSNPs, and the
excision repair cross-complementing rodent repair deficiency, complementation group 6 (ERCC6) with 16 ns-cSNPs.