In marked contrast, NAC treatment did not rescue the nucleotide excision repair
mutants [[XPA.sup.-/] and [XPG.sup.-/] (Xeroderma pigmentosum complementation group G)l (Table 4).
This damage is usually repaired by a process called nucleotide excision repair
, which cuts out and replaces sections of damaged DNA.
Furthermore, building on theefforts of PharmaMar to understand the mechanism of action of the drug candidates and products in the pipeline, data will show efficacy of Yondelis and PM01183 in cells derived from patients that lack specific factors of the DNA repair mechanism NER (nucleotide excision repair
) (Abstract #57, Nov.
Apurinic/apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1, APEX1, here referred to as APE1) has multifunctions as a base excision repair
enzyme and as a redox coactivator of a number of important transcription factors.
Nucleotide excision repair
pathway involved in the DNA repair processes plays an important role in the efficacy of chemotherapy.
1992) and incision steps of nucleotide excision repair
(NER), even at low concentrations (Hartwig 1998; Hartwig et al.
Bulky DNA adducts by cisplatin are mainly repaired by the mechanism of nucleotide excision repair
pathway (NER).2,3 During the NER pathway, the proteins of the excision repair
cross complementing 1 (ERCC1) and ribonucleotide reductase subunit M1(RRM1) play an important role in this pathway.
Millikan of the University of North Carolina at Chapel Hill and his colleagues document findings suggesting that specific combinations of polymorphisms on certain nucleotide excision repair
(NER) genes may modify the risk of breast cancer in black women who smoke.
It is well known that there are five main DNA repair pathways with more than 130 genes, of which the nucleotide excision repair
(NER) pathway plays a crucial DNA repair mechanism by removing various DNA lesions caused by UV radiation and some chemical agents, such as bulky adducts, cross links, oxidative DNA and alkylating damage and thymidine dimers.6-8 It is reported that xeroderma pigmentosum (XP) complementation groups in human, XPA to XPG, represent the ratelimiting proteins in the NER pathway.
In the present study we used individual-level exposure data and biologic samples to investigate the effects of As exposure on nucleotide excision repair
in two study populations, focusing on the excision repair
cross-complement 1 (ERCC1) component.
Defective nucleotide excision repair
in XPC mutant mice and its association with cancer predisposition.
More than 15 ns-cSNPs were detected in five genes: insulin-like growth factor receptor 2 (IGF2R) with 21 ns-cSNPs, REV3-like, catalytic subunit of DNA polymerase zeta (REV3L) with 21 ns-cSNPs, protein kinase, DNA-activated, catalytic polypeptide (PRKDC) with 20 ns-cSNPs, exonuclease 1 (EXO1) with 17 ns-cSNPs, and the excision repair
cross-complementing rodent repair deficiency, complementation group 6 (ERCC6) with 16 ns-cSNPs.