By using a simple protocol (Table), it should be possible to gather evidence using a case-control format comparing the frequency of a secondary flavivirus antibody response in convalescent-phase serum samples of persons experiencing any defined acute Zika virus disease syndromes, such as
exanthematous fever, congenital Zika syndrome, or GBS (i.e., case-patients) with the prevalence of past DENV infection in Zika virus-infected age-, sex-, residence-, and ethnicity-matched persons from the same exposure group (i.e., controls).
Peripheral polyneuropathy commonly occurs following
exanthematous fevers and as a complication of various acute bacterial infections, but it is highly doubtful whether there is direct invasion of the nerves by micro-organisms.The causative association of peripheral neuropathy with tuberculous infection is controversial.