Linear regression analysis was performed to assess the effect of cohort size on euploidy
rate adjusted for the effect of female age Lehert et al., Comparison of number 3 2010 of retrieved oocytes (primary endpoint) between two modalities of gonadotropin treatment, using the random effects model.
In fact, according to the results of our study, both the aneuploidy and euploidy rates do not vary according to ovarian response, whereas the number of euploid and aneuploid embryos increases in the same way as number of oocytes does.
Caption: Figure 3: Correlation between ovarian response and gonadotropins doses and the aneuploidy rate (a and b) and euploidy rate (c and d), respectively.
"If, in a woman less than 36, there is evidence of recurrent euploidy
, that's not an indication for preimplantation genetic diagnosis.
A statistically significant change (e.g., using z-score statistics) in the number of reads mapped to a chromosome of interest (such as chromosome 21) is used to identify fetal an euploidy
. The accuracy of the test is largely dependent on 2 factors: the variability (SD) of the percentage of reads mapped to the chromosome of interest among euploidy
samples and the absolute difference between the sample being tested and the mean of the euploidy
First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of an euploidy
. Fertil Steril.
What remains unknown, however, is what portion of the discordancy between NIPT and fetal results is attributable to the demarcation between euploidy
and aneuploidy established by the statistical algorithms, and how much is due to biologic explanations uncovered by the greater sensitivity of MPS.
Aneuploidy embryos are more likely to be blocked on day 3 than the euploidy
Women with euploidy
pregnancies who visited the KK Women's and Children's Hospital, Singapore, were recruited.
Detection of an euploidy
in chromosomes X, Y, 13, 18 and 21 by QF-PCR in 662 selected pregnancies at risk.