embryos were identified via 24-chromosome PGS using either an array-based comparative genomic hybridization or an array-based single nucleotide-polymorphism method, as previously described. Selected embryos were vitrified, warmed, and transplanted as previously described.
Costa and Grybko  observed a small but significant reduction on the levels of CA1 LTP induced by TBS in hippocampal slices from Ts65Dn mice compared with euploid
PGD is advised in cases where a specific aberration is isolated (single-gene disorders, inherited genetic diseases, and X-linked mutations), while PGS is carried out in infertile patients for the purpose of selecting the most viable euploid
The number of euploid
embryos identified by PGS from each of the 724 cycles analysed was then correlated with the number of oocytes retrieved in that cycle.
The recommendations state that euploid
embryo transfer should be limited to one for women of any age with a favorable prognosis, and for women younger than 35 years regardless of the embryo stage.
The patient underwent 2 stimulation cycles in a GnRH-antagonist protocol; however there was no euploid
embryo after PGS, so no embryo transfer was done.
Notwithstanding, this does not mean that an euploid
embryo will necessarily implant and develop as some other reasons such as inappropriate endometrial receptivity might also cause implantation failure even in normal embryos [47-50].
Accordingly, in Results, the text reading "The number of euploid
embryos was negatively related to the OSI (p = 0.04), which indicates that the women who produced more oocytes in response to lower gonadotropin doses (low OSI) were those who displayed more euploid
" should be changed to "The number of euploid
embryos was positively related to the OSI (p = 0.04), which indicates that the women who produced more oocytes in response to lower gonadotropin doses (high OSI) were those who displayed more euploid
Blastocysts needed to transfer at least one euploid
embryo: data from 10,852 pre-implantation genetic screening (PGS) cycles, Fertility and Sterility.
In a case diagnosed as complete trisomy 9 by conventional cytogenetic techniques, fluorescence in situ hybridization (FISH) studies of metaphase and interphase blood cells and skin fibroblasts could identify the presence of euploid
and trisomy 9 cells.
Of the 10 embryos subjected to array CGH, 2 failed to amplify, 2 were euploid
, 4 were aneuploid and 2 had unbalanced translocations.
GSE 1281 included six Down syndrome samples and six normal samples, which were from newborn rat brain tissue; GSE 1611 contained 12 samples (Ts1Cje and euploid
Down syndrome cerebellum) as follows: two Down syndrome samples at postnatal days 15 and 30, respectively, and two normal samples of newborn at postnatal days 15 and 30, respectively.