The researchers identified 42 reports of
euglycemic diabetes ketoacidosis (EDKA) and five cases of hyperglycemic diabetic ketoacidosis (HDKA) from 33 publications.
However, caution is needed because of the potential risk of
euglycemic ketoacidosis, whose incidence was slightly increased with SGLT-2 inhibitors mainly in type 1 diabetes, sometimes provoked by alcohol excess, surgery, or intercurrent disease (30, 33, 34).
Euglycemic control animals received an equal volume of citrate buffer.
Rest 53% patients of frozen shoulder were found to be
euglycemic. 41% patients had history of diabetes mellitus in their immediate family.
Inclusion criteria were: age older than eighteen years, newly diagnosed cases of ALL,
euglycemic at diagnosis.
All these observations suggest that the genetically susceptible non-diabetic offspring of diabetic parents, even in their
euglycemic state, have alterations in the autonomic regulation of cardiovascular system.
According to a revision carried out by Wallace et al (25) this surrogate had shown a good correlation when compared with the
euglycemic clamp (r=0.58-0.88, p<0.0001).
Literature has exhibited that replacing vitamin D decreases HbA1c level and maintains
euglycemic status.
The gold standard,
euglycemic hyperinsulinemic clamping is clearly inadequate in view of its high cost and complexity.
(18,27) Concerns center around its osmotic diuretic effect, which can lead to dehydration, an increased frequency of genital infections, and, less commonly,
euglycemic ketoacidosis.
The CHMP's decision was based on analytical similarity data, metabolic assays, and
euglycemic clamp data in type 1 diabetes patients for demonstration of similar PD and PK response.