Banningetal., "Disruption of the gene
euchromatin histone methyl transferase1 (Eu-HMTase1) is associated with the 9q34 subtelomeric deletion syndrome," Journal of Medical Genetics, vol.
The nuclei of these cells showed
euchromatin regions which signified an intense cellular activity.
As shown by morphology observation, the cells exposed 12 h to 150 [micro]M [H.sub.2][O.sub.2] exhibited a typical oxidative injury including multiple membranous vacuoles in the cytoplasm, disruption of endoplasmic reticulum and mitochondrion, and condensing
euchromatin in cell nucleus.
The previously well-marked areas of
euchromatin and heterochromatin within the structure of cellular nuclei became diffused.
They also indicated centromeric fusions and additions/deletions of C-heterochromatin, as well as occasional pericentric inversions,
euchromatin deletions, missing chromosomes and centromeric shifts, as major mechanisms of chromosomal change.
The intensity of Hoechst staining of DNA in compact chromatin regions, such as heterochromatin, is much more intense then Hoechst intercalated into looser regions of chromatin, such as
euchromatin; therefore, the difference in Hoechst intensity can be used to determine the degree of compaction observed across nuclei (Belloc et al.
Histone variant H2A.Z marks the 59 ends of both active and inactive genes in
euchromatin. Cell 2005; 123:233-48.
The ultrastructural study of untreated diabetic group revealed a reduction in the density of mitochondria in addition to predominance of
euchromatin over heterochromatin in the nucleus of parietal cells as compared with the control group.
DNA exists inside of a cell's nucleus in two forms:
euchromatin and heterochromatin.
Histone proteins are involved in the dynamic organization of DNA into zones of active
euchromatin and inactive heterochromatin in a process that is regulated, in part, by a complex series of posttranslational modifications to histone tails, including acetylation and methylation.
Chromosomal fusions were common, with breakpoints clustered in regions of high transcriptional activity (transcriptomes located in
euchromatin).
These two enzymes are working as opposites because HATs will cause chromatin structure to stretch into
euchromatin [25].
