This study examined efficacy and safety in Japanese patients diagnosed with generalized pustular psoriasis (GPP) who have had an inadequate response to conventional therapy (e.g., etretinate
Bukhari, "Impetigo herpetiformis in a primigravida: successful treatment with etretinate
," Journal of drugs in dermatology : JDD, vol.
The second-generation retinoids are the monoaromatics (etretinate
, acitretin, and motretinate).
Furukawa, "The vitamin A derivative etretinate
improves skin sclerosis in patients with systemic sclerosis," Journal of Dermatological Science, vol.
1 mg/kg/day is helpful in some cases, but the lesions recur.
In some cases of treatment-resistant and unresectable cancers, etretinate
has provided partial improvement [1, 6].
A Japanese study combined the use of low-dose etretinate
(0.3-0.5 mg/kg per day) and EPA and compared it with the high-dose etretinate
In 2003, the agency withdrew Tegison[R] (etretinate
Acitretin, a synthetic retinoid, is the pharmacologically active metabolite of etretinate
. Acitretin is currently approved by the US Food and Drug Administration for the treatment of severe psoriasis in adults.
Sensory neuropathy associated long-terme etretinate
The skin lesions healed after several treatments with different drugs, including etretinate
and chloroquine, but visible scars developed in the areas where the lesions have been present.
You cannot donate blood if you have ever taken etretinate
(Tegison) or human pituitary-derived growth hormone.