etomidate


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etomidate

 [ĕ-tom´ĭ-dāt]
a sedative and hypnotic, administered intravenously for induction and maintenance of general anesthesia and as a supplement to low-potency anesthetics for maintenance of anesthesia during short operative procedures.

etomidate

/etom·i·date/ (ĕ-tom´ĭ-dāt) a sedative-hypnotic, administered intravenously for the induction and maintenance of anesthesia.

etomidate

[etom′idāt]
a short-acting, hypnotic nonbarbiturate IV agent used for induction of general anesthesia. It has minimal adverse cardiovascular and respiratory effects, thus providing a greater margin of safety in patients with or at risk for heart disease. Adverse effects include transient reduction in adrenal gland cortisol release, pain on injection, and involuntary muscle movements.

etomidate

A general anaesthetic drug. A brand name is Hypnomidate.

etomidate

an intravenous, nonbarbiturate, fast-inducing anesthetic with no analgesic effect. Also causes suppression of adrenal steroidogenesis and may be used in the treatment of hyperadrenocorticism.
References in periodicals archive ?
3 mg/kg of etomidate (Etomidate-Lipuro) and 5 [micro]g/kg of fentanyl (Fentanyl).
Steroidogenesis can be directly inhibited by agents such as ketoconazole, metyrapone, mitotane, aminoglutethimide, ortho-paradichlorodiphenyldichloroethane, and etomidate (15).
Midazolam is more likely to cause hypotension than etomidate in emergency department rapid sequence intubation.
The traditional link between anaesthesia and intensive care has led to an extended, albeit modified use of hypnotics and analgesics such as benzodiazepines, propofol, etomidate and different opiates as sedatives in intensive care units (ICU) over a prolonged period of time.
Etomidate is no longer recommended for this indication in septic shock because of the risk of adrenal suppression.
In contrast, the mutation did not affect the receptor's sensitivity to GABA or the modulation by zinc, the benzodiazepine flunitrazepam, or the anesthetic etomidate (Werner et al.
Imidazole can be found in many other drugs such as dacarbazine, metronidazole, cimetidine, flumazenil, thyroliberin, methimazole, pilocarpine and etomidate which are used as antineoplastic antibiotic, antiulcerative, benzodiazepine antagonist, prohormone, antihyperthyroid, muscarinic receptor antagonist and hypnotic agents, respectively [8-11].
The agents inhibiting steroidogenesis include: metyrapone, ketoconazole, mitotane, aminoglutethimide, trilostane, etomidate.
In both groups, etomidate did not attenuate the hypertensive response associated with ECT and resulted in significantly higher mean MAP post-ECT at three minutes.
In addition to its primary product Actiq, the Company has additional investigational product candidates in clinical development: OTS(TM) nicotine for smoking cessation, OTS fentanyl for acute pain management, OTS etomidate for short-acting sedation, OTS piroxicam for mild to moderate pain, OTS droperidol and OTS prochlorperazine for nausea and vomiting, and OTS scopolamine for motion sickness.
Tenders are invited for Procurement of general drugs for the year 2014-2015 Etomidate Lipuro Inj.