etodolac


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etodolac

 [e-to-do´lak]
a nonsteroidal antiinflammatory drug used as an analgesic and antiinflammatory, especially to treat arthritis; administered orally.

etodolac

Apo-Etodolac (CA), Eccoxolac (UK), Gen-Etodolac (CA), Taro-Ultradol, Ultradol (CA)

Pharmacologic class: Pyranocarboxylic acid, nonsteroidal anti-inflammatory drug (NSAID)

Therapeutic class: Nonopioid analgesic

Pregnancy risk category C (first and second trimesters), D (third trimester)

Pregnancy risk category C (first and second trimesters), D (third trimester)

Action

Blocks activity of cyclooxygenase (which is needed for prostaglandin synthesis), easing pain and reducing inflammation

Availability

Capsules: 200 mg, 300 mg

Tablets: 400 mg, 500 mg

Tablets (extended-release): 400 mg, 500 mg, 600 mg

Indications and dosages

Osteoarthritis; rheumatoid arthritis

Adults: 300 mg P.O. two or three times daily; or 400 mg, 500 mg, or 600 mg P.O. b.i.d.; or 400 to 1,000 mg P.O. (extended-release tablets) once daily

Mild to moderate pain

Adults: 200 to 400 mg P.O. q 6 to 8 hours, not to exceed 1,200 mg/day

Contraindications

• Hypersensitivity to drug or its components
• Concurrent use of other NSAIDs
• Active GI bleeding or ulcer disease

Precautions

Use cautiously in:
• severe cardiovascular, renal, or hepatic disease
• elderly patients
• breastfeeding patients
• children (safety not established).

Administration

• Give with food or antacids to reduce GI upset.
• Make sure patient swallows extended-release tablets whole without crushing or chewing.
• Withhold drug several days before invasive surgery, as ordered.

Adverse reactions

CNS: dizziness, malaise, weakness, depression, nervousness

CV: hypertension

EENT: blurred vision, tinnitus

GI: nausea, vomiting, constipation, diarrhea, flatulence, dyspepsia, peptic ulcer, duodenitis, intestinal ulceration, gastritis, melena

GU: dysuria, urinary frequency, polyuria, renal failure

Hematologic: thrombocytopenia

Hepatic: cholestatic jaundice, cholestatic hepatitis, hepatic necrosis

Skin: rash, skin peeling, cutaneous vasculitis with purpura, hyperpigmentation

Other: fluid retention, chills, fever, allergic reaction

Interactions

Drug-drug.Aminoglycosides: elevated aminoglycoside blood level (in premature infants)

Anticoagulants: prolonged prothrombin time

Beta-adrenergic blockers: reduced antihypertensive effect

Bisphosphonates: increased risk of gastric ulcers

Cholestyramine: decreased etodolac absorption

Cyclosporine: increased risk of nephrotoxicity

Diuretics: decreased diuretic effect

Lithium: increased lithium blood level, greater risk of toxicity

Methotrexate: increased risk of methotrexate toxicity

Phenylbutazone: increased etodolac effects

Phenytoin: increased phenytoin blood level

Salicylates: decreased etodolac blood level

Drug-diagnostic tests.Bleeding time: prolonged

Blood urea nitrogen (BUN), creatinine, hepatic enzymes: increased levels

Urine bilirubin, urine ketones: falsepositive results

Drug-herbs.Arnica, chamomile, clove, dong quai, feverfew, garlic, ginkgo, ginseng: increased risk of bleeding

White willow: increased etodolac effects

Drug-behaviors.Alcohol use: increased risk of adverse effects

Sun exposure: phototoxicity

Patient monitoring

• Monitor CBC, liver function tests, BUN, creatinine level, and coagulation studies.
• Assess for GI bleeding and gastric upset. Administer antacids as needed and prescribed.
• Know that drug may cause falsepositive urine bilirubin and urine ketone test results.

Monitor patient for signs and symptoms of thrombocytopenia and increased bleeding time.
• Assess for fluid retention and weigh patient daily.
• Watch for decreased blood pressure control in hypertensive patients.

Patient teaching

• Instruct patient to take with meals if possible.
• Tell patient to swallow extendedrelease tablets whole without crushing or chewing.

Instruct patient to immediately report unusual bleeding or bruising, change in urination pattern, unusual tiredness, or yellowing of skin or eyes.
• Advise patient to avoid activities that can cause injury.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

etodolac

/eto·do·lac/ (e-to-do´lak) a nonsteroidal antiinflammatory drug used as an analgesic and antiinflammatory, especially to treat arthritis.

etodolac

(ĭ-tō′də-lăk)
n.
A nonsteroidal anti-inflammatory medication, used especially for the treatment of osteoarthritis.

etodolac

[etodo′lak]
a nonsteroidal antiinflammatory drug used as an analgesic and antiinflammatory agent, especially to treat arthritis. It is administered orally.

etodolac

A NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) used to treat RHEUMATOID ARTHRITIS. A brand name is Lodine.

etodolac

propionic acid; non-steroidal anti-inflammatory drug used to control pain and inflammation in rheumatoid disease and osteoarthritis

etodolac

(ētō´dəlak),
n brand name: Lodine;
drug class: nonsteroidal antiinflammatory;
action: inhibits prostaglandin synthesis by interfering with cyclooxgenase, which is needed for biosynthesis;
uses: mild to moderate pain, osteoarthritis.

etodolac

a nonsteroidal anti-inflammatory COX-2 inhibitor used for its analgesic effect in dogs, primarily that associated with osteoarthritis.
References in periodicals archive ?
She was diagnosed as DRESS syndrome caused by the CM and etodolac due to (1) the close relationship between the initiation of CM and etodolac and the onset of symptoms, (2) the elimination rate of CM and etodolac in elderly patients are reduced related to the reduction in renal function and aging,[sup][6] (3) the risk of acute nephrotoxicity of NSAIDs increases with age,[sup][7] (4) fever, (5) skin rash with facial edema, (6) typical laboratory tests included the presence of eosinophilia and atypical lymphocytes, (7) a positive finding of CMV infection which is associated with the development of DRESS, (8) multiple organ involvement including the liver, kidney, lung, and pancreas, and (9) persistent and worsening symptoms after withdrawal from the causative drug.
Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective nonsteroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats.
NASDAQ: TARO) has reported that Taro Pharmaceuticals (UK) Limited (Taro UK), its affiliate in the United Kingdom, has been granted a marketing authorization for Etopan XL Tablets 600 mg, Etodolac (Etopan XL) by the Medicines and Healthcare Products Regulatory Agency, the UK equivalent of the U.
The non-selective NSAIDs examined in the review were diclofenac, etodolac, ibuprofen, indomethacin, ketoprofen, ketorolac, meloxicam, nabumetone, naproxen, nimesulide and piroxicam (which is still being assessed)
In addition, anti-inflammatory and other medications were included in the protocols in five different studies that we examined (piroxicam, (15) ibuprofen, (4) DayPro (oxaprozin), (13) and celecoxib (2) once each, and one trial that used dexamethasone sodium phosphate, bupivacaine hydrochloride and Etodolac (or piroxicam) and potentially dexamethasone acetate if patients did not respond to the previous medications).
The mainstay of conventional medicine involves long-term administration of nonsteroidal anti-inflammatory drugs (NSAIDS), most commonly etodolac (Eto-Gesic) or carprofen (Rimadyl).
04 (100 mg/day)] divided has stated that doses available data suggest that use etodolac $1.
Prescription NSAIDs include indomethacin (Indocin[R]), naproxen (Anaprox[R], Naprosyn[R], Naprelan[R]), ketoprofen (Oruvail[R]), nabumetone (Relafen[R]), flurbiprofen (Ansaid[R], diclofenac (Arthrotec[R], Cataflam[R], Voltaren[R]), etodolac (Lodine[R]), meloxicam (Mobic[R]), sulindac (Clinoril[R]), oxaprozin (Daypro[R]), and piroxicam (Feldene[R]).
These included etodolac, oxaprozin, rofecoxib, acetaminophen combinations with codeine, hydrocodone, and oxycodone, and a muscle relaxant.
Otros medicamentos de uso comun erroneo, relacionados con alteraciones auditivas, son los antiinflamatorios no esteroides, ibuprofeno, naproxen sodico, sulindac, piroxicam, indometacina, trihidrato de indometacina sodica, etodolac, fenoprofeno calcico y diclofenaco sodico, furosemida, acido ectacrinico, bumetamida y algunos antibioticos administrados por via intravenosa.
NSAIDs Used To Treat Lupus(*) Generic Name Brand Name Ibuprofen Motrin, Advil Naproxen Naprosyn, Aleve Sulindac Clinoril Diclofenac Voltaren Piroxicam Feldene Ketoprofen Orudis Diflunisal Dolobid Nabumetone Relafen Etodolac Lodine Oxaprozin Daypro Indomethacin Indocin (*) Brand names included in this fact sheet are provided as examples only and their inclusion does not mean that these products are endorsed by the National Institutes of Health or any other Government agency.
2 million capsules of the arthritis drug etodolac because they are contaminated with another drug that could cause life-threatening problems in some patients.