etodolac


Also found in: Dictionary, Thesaurus, Wikipedia.

etodolac

 [e-to-do´lak]
a nonsteroidal antiinflammatory drug used as an analgesic and antiinflammatory, especially to treat arthritis; administered orally.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

etodolac

Apo-Etodolac (CA), Eccoxolac (UK), Gen-Etodolac (CA), Taro-Ultradol, Ultradol (CA)

Pharmacologic class: Pyranocarboxylic acid, nonsteroidal anti-inflammatory drug (NSAID)

Therapeutic class: Nonopioid analgesic

Pregnancy risk category C (first and second trimesters), D (third trimester)

Action

Blocks activity of cyclooxygenase (which is needed for prostaglandin synthesis), easing pain and reducing inflammation

Availability

Capsules: 200 mg, 300 mg

Tablets: 400 mg, 500 mg

Tablets (extended-release): 400 mg, 500 mg, 600 mg

Indications and dosages

Osteoarthritis; rheumatoid arthritis

Adults: 300 mg P.O. two or three times daily; or 400 mg, 500 mg, or 600 mg P.O. b.i.d.; or 400 to 1,000 mg P.O. (extended-release tablets) once daily

Mild to moderate pain

Adults: 200 to 400 mg P.O. q 6 to 8 hours, not to exceed 1,200 mg/day

Contraindications

• Hypersensitivity to drug or its components

• Concurrent use of other NSAIDs

• Active GI bleeding or ulcer disease

Precautions

Use cautiously in:

• severe cardiovascular, renal, or hepatic disease

• elderly patients

• breastfeeding patients

• children (safety not established).

Administration

• Give with food or antacids to reduce GI upset.

• Make sure patient swallows extended-release tablets whole without crushing or chewing.

• Withhold drug several days before invasive surgery, as ordered.

Adverse reactions

CNS: dizziness, malaise, weakness, depression, nervousness

CV: hypertension

EENT: blurred vision, tinnitus

GI: nausea, vomiting, constipation, diarrhea, flatulence, dyspepsia, peptic ulcer, duodenitis, intestinal ulceration, gastritis, melena

GU: dysuria, urinary frequency, polyuria, renal failure

Hematologic: thrombocytopenia

Hepatic: cholestatic jaundice, cholestatic hepatitis, hepatic necrosis

Skin: rash, skin peeling, cutaneous vasculitis with purpura, hyperpigmentation

Other: fluid retention, chills, fever, allergic reaction

Interactions

Drug-drug. Aminoglycosides: elevated aminoglycoside blood level (in premature infants)

Anticoagulants: prolonged prothrombin time

Beta-adrenergic blockers: reduced antihypertensive effect

Bisphosphonates: increased risk of gastric ulcers

Cholestyramine: decreased etodolac absorption

Cyclosporine: increased risk of nephrotoxicity

Diuretics: decreased diuretic effect

Lithium: increased lithium blood level, greater risk of toxicity

Methotrexate: increased risk of methotrexate toxicity

Phenylbutazone: increased etodolac effects

Phenytoin: increased phenytoin blood level

Salicylates: decreased etodolac blood level

Drug-diagnostic tests. Bleeding time: prolonged

Blood urea nitrogen (BUN), creatinine, hepatic enzymes: increased levels

Urine bilirubin, urine ketones: falsepositive results

Drug-herbs. Arnica, chamomile, clove, dong quai, feverfew, garlic, ginkgo, ginseng: increased risk of bleeding

White willow: increased etodolac effects

Drug-behaviors. Alcohol use: increased risk of adverse effects

Sun exposure: phototoxicity

Patient monitoring

• Monitor CBC, liver function tests, BUN, creatinine level, and coagulation studies.

• Assess for GI bleeding and gastric upset. Administer antacids as needed and prescribed.

• Know that drug may cause falsepositive urine bilirubin and urine ketone test results.

Monitor patient for signs and symptoms of thrombocytopenia and increased bleeding time.

• Assess for fluid retention and weigh patient daily.

• Watch for decreased blood pressure control in hypertensive patients.

Patient teaching

• Instruct patient to take with meals if possible.

• Tell patient to swallow extendedrelease tablets whole without crushing or chewing.

Instruct patient to immediately report unusual bleeding or bruising, change in urination pattern, unusual tiredness, or yellowing of skin or eyes.

• Advise patient to avoid activities that can cause injury.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

etodolac

(ĭ-tō′də-lăk)
n.
A nonsteroidal anti-inflammatory medication, used especially for the treatment of osteoarthritis.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

etodolac

A NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) used to treat RHEUMATOID ARTHRITIS. A brand name is Lodine.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
All the NSAIDs (diclofenac, dipyrone, etodolac, and ketoprofen) produced significant analgesic effects in the hot plate test (p<0.01 and p<0.001).
She was diagnosed as DRESS syndrome caused by the CM and etodolac due to (1) the close relationship between the initiation of CM and etodolac and the onset of symptoms, (2) the elimination rate of CM and etodolac in elderly patients are reduced related to the reduction in renal function and aging,[sup][6] (3) the risk of acute nephrotoxicity of NSAIDs increases with age,[sup][7] (4) fever, (5) skin rash with facial edema, (6) typical laboratory tests included the presence of eosinophilia and atypical lymphocytes, (7) a positive finding of CMV infection which is associated with the development of DRESS, (8) multiple organ involvement including the liver, kidney, lung, and pancreas, and (9) persistent and worsening symptoms after withdrawal from the causative drug.
As appearing from the loadings in Figure 2(b), (1) basic drugs, terfenadine, toremifene, nadolol, carvedilol, and haloperidol, and (2) acidic drugs, diclofenac and etodolac, have a big weight on PC1 and PC2, respectively, in comparison to the other drugs, which indicate that they play a main role in column classification.
Traditional NSAID use (diclofenac, etodolac, and meloxicam) is also associated with decreased risk in developing aggressive skin cancers, whereas "more selective" to COX-2 inhibitors were not found to be protective [133,134].
Those taking a specific COX-2 called etodolac were 53% more likely to die from stroke compared to non-users.
The product is a novel, chrono-modulated combination of the non-selective beta-adrenergic receptor blocker, propranolol, and the COX-2-selective non-steroidal anti-inflammatory drug (NSAID), etodolac.
The applications of non-classical bioisosterism have also been reported in a number of areas of pharmacology including adrenergic and anti adrenergic drugs [28, 30-31] , several NSAID classes like aryl acetic acid derivatives [32], cetroplac, tolmetin, indomethacin, etodolac [5], antibacterial drugs [33] , antidepressant of morpholine class [34] , neuropeptide substance P antagonists (NK1 antagonists) [35], cholinergic (muscarinic type) agonists [36], GABA modulators like muscimol, thiomuscimol, isomuscimol as agonists [37-38], peptidomimetics [39], diuretics like ethacrinic acid [5] and 5-hyderoxy tryptamine (5-HT1A;1D) agonists like naratryptan and sumatryptan for acute attack of migraine [40].
Etodolac (1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4b]-indole-1-aceticacid, ETD, Figure 1(b)) isapotent andwelltolerated nonsteroidal anti-inflammatory drug (NSAID), and is indicated for the treatment of acute pain and for the signs and symptoms of rheumatoid arthritis and osteoarthritis [3].
A eficacia dos diferentes AINEs, sejam COX-2 seletivos (celecoxibe), parcialmente seletivos (meloxican, nabumetone e etodolac) ou classicos (nao seletivos--diclofenaco, naproxeno, ibuprofeno, indometacina, dentre outros), foi semelhante quando a dose de cada medicamento e empregada com mesma extensao.
Sargent Jr., 41, of 14 Dresser St., Webster, charged with possession of etodolac, dismissed without prejudice.