ethynodiol

ethynodiol

 [ĕ-thi″no-di´ol]
a progestational agent used, as the diacetate salt, in combination with an estrogen component as an oral contraceptive.
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Patients were treated with suppressive therapy that consisted of an oral contraceptive (OC) (35 [micro]g ethinyl estradiol plus 1 mg ethynodiol diacetate), an antiandrogen (spironolactone 200 mg/day), or a combination of these drugs.
M2 EQUITYBITES-December 29, 2016-Mylan NV introduces Ethynodiol Diacetate and Ethinyl Estradiol Tablets in the USA
M2 PHARMA-December 29, 2016-Mylan NV introduces Ethynodiol Diacetate and Ethinyl Estradiol Tablets in the USA
TABLE 3 A look at 4 generations of progestins (6) First generation Ethynodiol diacetate Norethindrone Second generation Levonorgestrel Norgestrel Third generation Desogestrel Etonogestrel * Gestodene ([dagger]) Norgestimate Norelgestromin ([double dagger]) Fourth generation Dienogest Drospirenone * Metabolite of desogestrel, contained in the vaginal ring and subdermal implant, ([dagger]) Currently not approved by the US Food and Drug Administration, but under review as a new patch.
The investigators found significant associations between breast cancer and recent use of OCs involving high-dose estrogen (OR, 2.7; 95% Cl, 1.1 6.2), ethynodiol diacetate (OR, 2.6; 95% Cl, 1.4-4.7), or triphasic dosing with an average of 0.75 mg of norethindrone (OR, 3.1; 95% Cl, 1.95.1).
Existing progestogen compounds can be classified as first- (e.g., norethisterone, norethindrone, ethynodiol diacetate, and lynestrenol), second- (levonorgestrel and norgestrel), and third-generation (desogestrel, gestodene, and norgestimate).
Combined OCPs administered to the patients included the following: desogestrel 0.15 mg/ethinyl estradiol 0.03 mg, desogestrel 0.15 mg/ethinyl estradiol 0.02 mg, desogestrel 0.15 mg/ethinyl estradiol 0.03 mg, ethynodiol diacetate 1 mg/ethinyl estradiol 0.035 mg, drospirenone 3 mg/ethinyl estradiol 0.03 mg, norgestimate 0.25 mg/ethinyl estradiol 0.035 mg and norethindrone 1 mg/ethinyl estradiol 0.05 mg.
The traditional POPs contain levonorgestrel, norethisterone or ethynodiol diacetate and act mainly by cervical mucus thickening and endometrial atrophy.
However, the present study is concurrent with the studies performed on synthetic steroids such as cyproterone acetate, ethynodiol diacetate, chlormadinone acetate, medroxyprogesterone acetate, norgestrel and megestrol acetate that induced CAs and SCEs with or without metabolic activation system [1,10,21,22,23,25,26].
The first progestin mini-pills (ethynodiol, linestrenol and norethisterone) were followed by levonorgestrel and then desogestrel; drospirenone is now being evaluated.
In contrast, all preparations containing the progestogen ethynodiol diacetate were associated with an increased incidence of fibroids, regardless of the quantity present or the type or amount of the accompanying estrogen.
Progesterone only contraceptives include Femulen (ethynodiol), Micronor (norethisterone) Microval (levonorgestrel).