ethacrynic acid


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ethacrynic acid

 [eth″ah-krin´ik]
a loop diuretic used orally in the treatment of edema, including that associated with congestive heart failure or hepatic or renal disease, ascites, and hypertension.

eth·a·cryn·ic ac·id

(eth'ă-krin'ik as'id),
An unsaturated ketone derivative of aryloxyacetic acid; a potent loop diuretic and a weak antihypertensive;

ethacrynic acid

/eth·a·cryn·ic ac·id/ (eth-ah-krin´ik) a loop diuretic used in the treatment of edema, including that associated with congestive heart failure or hepatic or renal disease, ascites, and hypertension.

ethacrynic acid

(ĕth′ə-krĭn′ĭk)
n.
A compound, C13H12Cl2O4, used as a diuretic primarily to treat severe edema.

ethacrynic acid

[eth′əkrin′ik]
a loop diuretic.
indications It is prescribed as a treatment for severe edema, such as nephrotic syndrome, hepatic cirrhoses, and ascites of malignancy. Unlike many other diuretics, ethacrynic acid is not a sulfonamide derivative and can therefore be tolerated by some people who develop hypersensitivity reactions to other diuretics.
contraindications Pregnancy, anuria, or known hypersensitivity to this drug prohibits its use. It is not given to infants.
adverse effects Among the more serious adverse effects are tetany, muscle weakness, cramps, and excessive diuresis. Hearing loss may occur.

ethacrynic acid

Etacrynic acid, a LOOP DIURETIC drug. A drug that acts on the tubules in the kidneys to interfere with the reabsorption of water and thus greatly increase the output of urine. A brand name is Edecrin.

eth·a·cryn·ic ac·id

(eth'ă-krin'ik as'id)
Unsaturated ketone derivative of aryloxyacetic acid; a potent loop diuretic and a weak antihypertensive;
References in periodicals archive ?
The company has also identified a class of molecules similar to ethacrynic acid.
In view of the positive preclinical data, we have decided to proceed with development of both options, an eyedrop formulation of ethacrynic acid and a class of molecules similar to ethacrynic acid," said Dr.
The TEKRON study results have no impact on Telor's ongoing Phase III multicenter trial of XARANO(TM), an intraocular ethacrynic acid formulation for the treatment of acute increases in intraocular pressure following cataract surgery.
The TEKRON Phase IIa trial studied a topical, once-a-day formulation of ethacrynic acid.
Ethacrynic acid is considered to be one of the specific inhibitors of GSTs (Wu et al.
Developmental stages Effector (I50) Larva Ethacrynic acid ([micro]M) 33.
Ethacrynic acid is a loop diuretic that was first introduced in the 1960s for treatment of congestive heart failure (CHF) and ascites (1-3) Although extremely potent, ethacrynic acid has been almost completely superseded by furosemide and bumetanide because ethacrynic acid has enhanced ototoxicity and vestibulotoxicity.
This result was seen for ethacrynic acid monotherapy (Patients 1 and 2) and with spironolactone as an augmenting agent (Patient 3).
Further basic science investigations into the renal physiology of ethacrynic acid would also be very useful.
Studies of tissue taken from human eyes show that ethacrynic acid doubles or triples the permeability of the trabecufar meshwork, allowing more fluid to drain from the eye, Epstein says.
The researchers tested ethacrynic acid in four men and one woman with very severe open-angle glaucoma.
In all five patients, reduction in intraocular pressure was observed after the infection of ethacrynic acid," the team writes in the May 1992 AMERICAN JOURNAL OF OPHTHALMOLOGY.