ethacrynate

ethacrynate

 [eth-ah-krin´āt]
a salt, ester, or the conjugate base of ethacrynic acid; the sodium salt has the same loop diuretic actions as the acid; administered parenterally.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
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The results showed that EA-CPT preferentially docks at the dimer interface at GST P1-1 and subsequent interaction with the enzyme resulted in docking of the ethacrynate ligands at both active sites (in the H-sites), with the Pt moiety remaining bound at the dimer interface.
However, the Pt(IV)-EA conjugate containing a cDDP core and two axial ethacrynate ligands did not readily release a Pt(II) species to exert a synergistic cytotoxic effect and had poor aqueous solubility.