etamsylate


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etamsylate

Ethamsylate, a haemostatic drug used to prevent dangerous brain haemorrhage in low birth weight babies and excessive menstrual bleeding in adults. A brand name is Dicynene.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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Patient Cause of PH Child-Pugh Acute Class bleed (1) 57y/F PBC A No (2) 74y/M Alcohol A No (3) 50y/M HCV A No (4) 51y/M HBV B Yes (5) 52y/F PBC B Yes Patient Preoperative drug Endoscopic findings (1) 57y/F None F0/IGV1 (2) 74y/M None F2/GOV2 (3) 50y/M None F3/GOV2 Aminomethylbenzoic acid 0.4 g Etamsylate 2 g (4) 51y/M Carbazochrome 80 mg F3/GOV2 Hemocoagulase 1IU Somatostatin 6 mg Carbazochrome 80 mg (5) 52y/F Hemocoagulase 1 IU F3/GOV2 Somatostatin 6 mg Patient Endoscopic Volume of treatment cyanoacrylate (1) 57y/F NBCA 3.5ml (2) 74y/M NBCA + EIS 3ml (3) 50y/M NBCA + EBL 3.5ml (4) 51y/M NBCA + EBL 2.5ml (5) 52y/F NBCA + EBL 1ml TABLE 2: Postoperative events including subsequent severe adverse event (SAE), patient outcome, and probable cause.
[7] To control them is achieved by local hypothermia using thermal and ultrasonic coagulation, [8] parenterally injecting fresh frozen plasma and its products, factors of blood clotting (isolated or in various combinations), aminocaproic acid, serine proteinase inhibitors (aprotinin), etamsylate, desmopressin, and several other drugs with different mechanisms of bleeding control.
and Etamsylate 10 ml I/V as pre-emptive analgesic and styptic respectively.
Vital signs were monitored throughout the procedure which was followed by administration of etamsylate (0.8 g, qd for 24 h).{Figure 2}{Figure 3}
Bladder catheter was inserted, vitamin K1 (konakion), rutozide trihidrate (rutascorbin), etamsylate (dicynone) and vitamin C were given, after which no further hematuria was observed.
In the postoperative period the patient was prescribed Ceftriaxone -- 1.0 x 2 times a day intramuscularly during 6 days, i/v infusion of 100 ml of aminocapronic acid 5% solution once, Dicynone (etamsylate) 2 ml intramuscularly 2 times a day, Ketonal (ketoprofen) 2 ml intramuscularly at night, 3 days.
Later, based on results as the common cause for nose bleeding in present study was Ehrlichia canis infection (8 dogs) were treated with Doxycycline @ 10 mg/kg, daily once for 28 days, parenteral Etamsylate @ 125 mg total dose, iv and cold pack was applied.
Therefore, careful surgical hemostasis, a large dose of hemostatic agent (2 units of haemocoagulase by intravenous injection and 2 units by intramuscular injection, respectively; a hemostatic mixture (normal saline 250 ml + etamsylate 3.0 g + carbenzamine 0.3 g + vitamin C 3.0 g), intravenous drip) and proper blood transfusion (whole blood volume 400 ml) were adopted, all these measures ensured the successful completion of the operation.
Bleeding hoof injury was treated with styptics, bandaging and control of hemorrhage if any by topical (Potassium permanganate powder) and Etamsylate Inj.