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Although important for physiologic control of female development and reproduction, and the coordination of many other tissues and organ systems to support reproduction, estrogens are also associated with the development of cancers of estrogen-responsive tissues such as breast, uterus, and pituitary.
However, its role in signaling cells to divide and multiply can trigger and promote abnormal growth of estrogen-responsive tissues. Minimizing estrogen, therefore, is a clear goal for estrogen-responsive conditions.
This repression may increase cellular oxidative DNA damage that ultimately can result in the formation of cancer in estrogen-responsive tissues such as the breast and female reproductive organs.