CYP19A1

(redirected from estrogen synthetase)

CYP19A1

A gene on chromosome 15q21.1 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP19A1 localises to the endoplasmic reticulum and catalyses the last steps of oestrogen biosynthesis—three successive hydroxylations of the A ring of androgens.

Molecular pathology
CYP19A1 mutations can up- or downregulate aromatase activity.
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Such mechanisms include the inhibition of intestinal reabsorption of estrogen excreted through the biliary system, reduction in the synthesis of estrogen by inhibition of human estrogen synthetase and a decrease in the glycemic index.19 The relationship between dietary intake of fiber and risk of breast cancer was examined in a meta-analysis involving 10 prospective studies.
There are several possible mechanisms by which phytoestrogens may exert their effects including interaction with estrogen receptors (Collins-Burrow 2000, Pearce 2003), displacement of estrogens from sex hormone binding globulin (Aldercreutz 1992, Hillerns 2005, Hodgert 2000), regulation of estrogen metabolism (Dai 2002, 2003) and inhibition of aromatase (estrogen synthetase) (Kao 1998).
(5,6) This is not surprising in light of the presence of both estrogen receptors and estrogen synthetase in human coronary vessels.
Estrogen synthetase in the horse: comparison of equine placental and rat liver NADPH-cytochrome c (P-450) reductase activities.

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