Azeria is initially targeting the essential pioneer factor FOXA1, which has shown to be pivotal in the tumour development and maintenance of Estrogen receptor positive
luminal breast cancer and is also thought to be critical in the development of prostate cancer.
Citation: Alexandra Van Keymeulen et al., "Lineage-Restricted Mammary Stem Cells Sustain the Development, Homeostasis, and Regeneration of the Estrogen Receptor Positive
Lineage," Cell Reports, 2017; 20 (7): 1525 DOI: 10.1016/j.celrep.2017.07.066
Estrogen Receptor Positive
(ER+) Breast Cancer - Pipeline Insights, 2016 Report envisage Pipeline Intelligence by identifying the key players along with their potential pipeline molecule.
Estrogen receptor positive
breast cancer cells have proteins that attract the hormones estrogen and/or progesterone as they float by in the blood.
According to the researchers, young women who are current or recent smokers and had been smoking a pack a day for at least 10 years, had a 60 percent increased risk of estrogen receptor positive
found 60 percent increased risk of developing one of the most common types of breast cancer called estrogen receptor positive
, in young women who smoked a pack of cigarettes daily, for more than ten years.
This study highlights BCL-2, a gene whose expression is known to have significance in estrogen receptor positive
Some women cannot tolerate estrogen deprivation, but for those with estrogen receptor positive
breast tumors, anastrazole significantly improves survival.
Aromasin is a prescription medicine for the adjuvant treatment of postmenopausal women with estrogen receptor positive
early breast cancer.
In all cases the invasive breast cancer was stage I or II, estrogen receptor positive
, and lymph node negative.
In estrogen receptor positive
disease, the late recurrences keep coming; you keep on getting them in years 5-9, 10-14, and 15-plus," he said.
While we do not have a chemoprevention strategy that directly targets the estrogen receptor-negative tumors of importance to high-risk patients, a reduction in estrogen receptor positive
tumors still is of value.