estrogen receptor assay

estrogen receptor assay

a microscopic examination of breast tumor tissue used to determine the probable response of a tumor to endocrine therapy.

estrogen receptor assay

Oncology The ER is a protein found in high concentrations in the cytoplasm of breast, uterus, hypothalamus, and anterior hypophysis cells; ER levels are measured to determine a breast CA's potential for response to hormonal manipulation–60% of breast CAs are 'estrogen positive';12 of ER-positive Pts respond favorably to anti-estrogen–tamoxifen citrate therapy, in contrast to <13 of ER-negative Pts. See 'Flare' phenomenon. Cf Progesterone receptor assay.
References in periodicals archive ?
This combination of in vitro techniques includes the GST-pulldown assay (CARLA test), which detects interactions between ER and a coactivator; a competition binding assay that assesses ligand interactions with the receptor; a yeast-based estrogen receptor assay (YES); and a luciferase reporter assay in cultured MCF-7 cells that reveals transcriptional activation.
four years ago and programmed to perform an estrogen receptor assay (see photograph, page 32).
Wittliff JL, Brown AM, Fisher B: Establishment of uniformity in steroid receptor determinations for protocol B-09 of the National Surgical Adjuvant Breast Project, in Sarfaty GA, Nash AR, Keightley DD (eds): Estrogen Receptor Assays in Breast Cancer: Laboratory Discrepancies and Quality Assurance.

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