estrogen receptor assay

estrogen receptor assay

Oncology The ER is a protein found in high concentrations in the cytoplasm of breast, uterus, hypothalamus, and anterior hypophysis cells; ER levels are measured to determine a breast CA's potential for response to hormonal manipulation–60% of breast CAs are 'estrogen positive';12 of ER-positive Pts respond favorably to anti-estrogen–tamoxifen citrate therapy, in contrast to <13 of ER-negative Pts. See 'Flare' phenomenon. Cf Progesterone receptor assay.
References in periodicals archive ?
Estrogen receptor assay in polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma of salivary gland origin.
This combination of in vitro techniques includes the GST-pulldown assay (CARLA test), which detects interactions between ER and a coactivator; a competition binding assay that assesses ligand interactions with the receptor; a yeast-based estrogen receptor assay (YES); and a luciferase reporter assay in cultured MCF-7 cells that reveals transcriptional activation.
This involves a system we bought from Zymark Corp., Hopkinton, Mass., four years ago and programmed to perform an estrogen receptor assay (see photograph, page 32).
When we acquired the robot, we had been performing most of the estrogen receptor assays for management of breast cancer cases in British Columbia.
(51.) Raam S, Gelman R, Cohen JL, et al: Estrogen receptor assay: Interlaboratory and intralaboratory variations in the measurement of receptors using dextran-coated charcoal technique: A study sponsored by ECOG.
A systematic comparison of three commercial estrogen receptor assays in a single clinical outcome breast cancer cohort.

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