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* Breakthrough bleeding may be due to progestin type; switching from an estrane to a gonane may reduce it
(46) An OC with a gonane rather than an estrane progestin may be beneficial as this class of progestins may provide more consistent hormonal effects on the endometrium.
The 2 most common contraceptive progestins are derived from 19-nortestosterone, and are classified as gonanes or estranes. (23)