Harper warned against the use of tetracyclines and erythromycin estolate
when treating pregnant women with acne.
A randomized, placebo-controlled trial of erythromycin estolate
chemoprophylaxis for household contacts of children with culture-positive bordetella pertussis infection.
Diosmetin, the main metabolite of diosmin, has been shown to exert protective effect on hepatocytes against cellular damage induced by erithromycine estolate
and tert-butylhydroperoxide in humans .
In case of patients allergic to penicillin, erythromycin base (not erythromycin estolate
, which is associated with cholestatic hepatitis in pregnancy) or clindamycin (Cleocin) can be used.
Anti peroxidation effect of Livex, an herbal formulation against erythromycin estolate
induced lipid peroxidation in rats.
In Colorado, azithromycin, clarithromycin, or erythromycin estolate
would be first-line treatments.
The exception is the estolate
salt, which has been associated with maternal hepatotoxicity when used during the second trimester and should be avoided during pregnancy Erythromycin is excreted into breast milk and is considered compatible with breast-feeding.
Erythromycin stearate, ethylsuccinate, and estolate
have been developed to overcome the bitter taste of erythromycin base.
In the review of 124 patients that she and her associates published in 2007, erythromycin estolate
or ethylsuccinate was administered to 80% of children, and 67% of these children showed at least a partial response, with a median response time of 2 months.