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A neoplasm of immature, poorly differentiated neuronal cells believed to arise from neuroepithelial precursors.
[esthesio- + neuroblastoma]
Farlex Partner Medical Dictionary © Farlex 2012


A rare malignant neuroectodermal tumour of the nasal cavity in the retrobulbar region, middle cranial fossa, near the cribriform plate. It is thought to arise from the olfactory membrane of the sinonasal tract.

Clinical findings
Bimodal age distribution, affecting those in the 2nd and 6th decades of life; presents as a unilateral nasal obstruction, epistaxis, anosmia and headache, accompanied by nonspecific symptoms similar to other intranasal lesions—i.e., congestion, rhinorrhoea.
Small round cell malignancies that occur in the sinonasal tract—e.g., sinonasal undifferentiated carcinoma, lymphoma, rhabdomyosarcoma and neuroendocrine carcinomas.

5-year survival 50–60%; late recurrence is common. Hyams’ grading system is used for grading; it incorporates architecture, rosette formation, mitoses, necrosis and pleomorphism, and correlates with survival.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Olfactory neuroblastoma ENT A tumor of the nasal cavity, retrobulbar region or middle cranial fossa Clinical Nonspecific, similar to other intranasal lesions, ie congestion, rhinorrhea DiffDx Lymphoma, plasmacytoma, embryonal rhabdomyosarcoma Prognosis 5-yr survival 50-60%; late recurrence is common
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Diagnosis and management of esthesioneuroblastoma. Curr Opin Otolaryngol Head Neck Surg.
Along with the clinical, histological findings and the subsequent improvement in his condition after resection, we confirmed the diagnosis of ectopic ACTH-secreting esthesioneuroblastoma. During his postoperative course, his potassium requirements significantly decreased and he no longer required medication for potassium repletion.
All patients with carcinoma, esthesioneuroblastoma, and neuroendocrine carcinoma were given postoperative radiotherapy.
Olfactory neuroblastoma (ONB), also known as Esthesioneuroblastoma, is a rare but distinct malignant neuroectodermal tumor arising from the olfactory epithelium of roof of nasal cavity and cribriform plate.
Some histologies are staged using other systems, for example, the Kadish system is used for staging esthesioneuroblastoma.
Also known as esthesioneuroblastoma, this neuroendocrine malignancy arises from the olfactory epithelium of the superior nasal cavity.
Following is coverage of pituituary tumors, olfactory groove meningiomas, esthesioneuroblastoma, clival lesions, and anterior skull base defects reconstruction, among other topics.
Sebire had esthesioneuroblastoma, tumors in her nasal and sinus cavity that disfigured her face and caused blindness, according to the AP.
Esthesioneuroblastoma (ENB) is an uncommon sinonasal tract tumor, and it is even more uncommon among all neoplasms.
Other histological entity include adenocarcinoma, melanoma, esthesioneuroblastoma and sinonasal undifferentiated carcinoma (SNUC).
Prognostic utility of Hyams histological grading and Kadish-Morita staging systems for esthesioneuroblastoma outcomes.