ester local anesthetic

ester local anesthetic

a class of local anesthetics with an ester chemical group that differentiates it from the amide group of local anesthetics. Ester local anesthetics include benzocaine, chloroprocaine, cocaine hydrochloride, procaine hydrochloride, Nesacaine, and tetracaine and are metabolized primarily by pseudocholinesterase. Because of rapid metabolism, most ester local anesthetics have a relatively short duration of action with the exception of tetracaine.
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7) As of 1996, the last remaining ester local anesthetic product in a dental cartridge, a combination of procaine and propoxycaine, was removed from the US market.
The plasma enzyme pseudocholinesterase is produced in the liver and functions to metabolize ester linkages of compounds in the plasma including succinylcholine, ester local anesthetics, and other medications.
DISCUSSION: Since the discovery of anesthetic effects of cocaine in 1884 by Carl Koller, and the investigation of its adverse effects by Sigmund Freud, the search for less toxic and less addictive substitute led to development of amide and ester local anesthetics.