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a primary form of thrombocytopenia, in contrast to secondary forms that are associated with metastatic neoplasms, tuberculosis, and leukemia involving the bone marrow, or with direct suppression of bone marrow by the use of chemical agents, or with other conditions.
essential thrombocytopeniaA condition of young adults with thrombotic complications occurring in <1⁄2 of cases, associated with vasocclusive headaches, erythromelalgia Treatment Conservative, anegrelide if Sx
es·sen·tial throm·bo·cy·to·pe·ni·a(ĕ-sen'shăl throm'bō-sī-tŏ-pē'nē-ă)
A primary form of this disorder (in contrast to secondary forms that are associated with metastatic neoplasms, tuberculosis, and leukemia involving the bone marrow, or with direct suppression of bone marrow by the use of chemical agents, or with other conditions).
decrease in number of platelets in circulating blood. See also purpura.
due to alloantibodies generated in response to blood transfusions or to maternal alloimmunization. Caused by the exposure of the platelets of a newborn animal to platelet alloantibodies which are present in the colostrum of the dam. Occurs in piglets as a syndrome of spontaneous hemorrhage at a few days of age. See also immune-mediated thrombocytopenia (below).
excessive utilization of thrombocytes at hemorrhage sites causes significant reduction in circulating platelets.
that associated with a drug being administered. Some drugs named as causing thrombocytopenia are phenylbutazone, diphenylhydantoin, sulfonamides, digitoxin and phenothiazine tranquilizers.
see megakaryocytic leukemia.
see immune-mediated thrombocytopenia (below).
a loss of platelets caused by the presence of antiplatelet antibodies which can be demonstrated by the platelet factor-3 (PF-3) release test and immunofluorescence of megakaryocytes. Platelet production may be normal or impaired, also caused by antibodies directed against megakaryocytes. Includes alloimmune, autoimmune and some drug-induced thrombocytopenias.
infectious cyclic thrombocytopenia
recurring cycles of parasitemia and reduced numbers of thombocytes in the peripheral blood are seen in dogs infected with Anaplasmaplatys. Clinical signs are rarely observed, but coinfection may potentiate clinical disease caused by E. canis.
see alloimmune thrombocytopenia (above).
that due to neoplastic invasion of the bone marrow.
a form of nonimmune-mediated platelet destruction caused by exposure of platelets to a damaged or artificial surface.
thrombin stimulates platelet aggregation and reduces circulating numbers.
live-virus vaccines may be associated with a transient, nonimmunogenic aggregation and reduction in numbers of platelets.