calicheamicin

(redirected from esperamicin)

calicheamicin

Any of a family of antitumour antibiotics derived from Micromonospora calichensis and Actinomadura verrucosospora, which have 4000-fold greater antitumoural activity than adriamycin, share a motif of double-triple-double carbon bonds (a so-called enediyene) and cleave DNA in a double-stranded fashion at specific DNA sequences.
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References in periodicals archive ?
Denny, "Oxygen dependence of the cytotoxicity of the enediyne anti-tumour antibiotic esperamicin A1," British Journal of Cancer Supplement, vol.