Cancer of the esophagus and esophagogastric junction
: data-driven staging for the seventh edition of the American Joint Committee on Cancer/International Union Against Cancer Cancer Staging Manuals.
Major Finding: Patients with esophageal adenocarcinoma and esophagogastric junction adenocarcinoma were significantly less likely to have a history of H.
Data Source: An Australian study of 269 patients with esophageal adenocarcinoma, 307 with esophagogastric junction adenocarcinoma, and 218 with esophageal squamous cell carcinoma, compared with 1,355 controls.
. In: Oppenheimer E, editor.
Recommendations for clinical staging (cTNM) of cancer of the esophagus and esophagogastric junction
for the 8th edition AJCC/UICC staging manuals.
Tsuwano et al., "Optimal surgical management for esophagogastric junction
carcinoma," General Thoracic and Cardiovascular Surgery, vol.
Location number n (%) 1: AEGJ 5 (1.7) 2: fornix 7 (2.3) 3: lesser curvature of the body 33 (10.9) 4: greater curvature of the body 21 (7.0) 5: anterior wall of the body 22 (7.3) 6: posterior wall ofthe body 46 (15.2) 7: across the angle 34 (11.3) 8: lesser curvature of the antrum 45 (14.9) 9: greater curvature of the antrum 17 (5.6) 10: anterior wall of the antrum 34 (11.3) 11: posterior wall of the antrum 34 (11.3) 12: APR 4 (1.3) AEGJ: across the esophagogastric junction
; APR: across the pyloric ring.
In Reply.--We appreciate the comments regarding the now-published "Template for Reporting Results of HER2 (ERBB2) Biomarker Testing of Specimens From Patients with Adenocarcinoma of the Stomach or Esophagogastric Junction
." As stated at the beginning of this and each biomarker reporting template, our intent is to assist pathologists in providing clinically useful and relevant information when reporting results of biomarker testing.
For patients with inoperable locally advanced, recurrent, or metastatic adenocarcinoma of the stomach or esophagogastric junction
for whom trastuzumab (Herceptin) is under consideration for therapy, assessment for tumor HER2 overexpression using immunohistochemistry (IHC) or in situ hybridization (ISH) is recommended by the National Comprehensive Cancer Network (NCCN).
The esophagogastric junction
(EGJ), the region between which the stratified squamous mucosa-lined esophagus ends and the columnar mucosa-lined stomach begins, can be defined anatomically, physiologically, endoscopically, and histologically as either muscular or mucosal in nature.
Specialized intestinal metaplasia, dysplasia, and cancer of the esophagus and esophagogastric junction
: prevalence and clinical data.
In some cases, all glands in a biopsy from the esophagogastric junction
stain extensively with AB, without having a single goblet cell (Figure 4, C).