Achalasia cardia is a primary esophageal motility disorder characterized by loss of esophageal peristalsis
and impaired or absent relaxation of lower esophageal sphincter in response to swallow1,2.
Recently, healthy volunteers have described improvement of esophageal peristalsis
after the administration of capsaicin (Yi, et al.
There were also clinically-measured improvements in esophageal peristalsis
, which helps further prevent reflux.
Effect of dry swallows and wet swallows of different volumes on esophageal peristalsis
sup] Esophageal achalasia is a comparatively rare disease which usually presents with esophageal motility dysfunction characterized by failure of esophageal peristalsis
and lack of relaxation of the lower esophageal sphincter.
GER can result in abnormal esophageal motility characterized by weakened primary esophageal peristalsis
Unlike the esophageal lining, laryngeal epithelium is not protected against chemical injury from gastric acid, as it lacks both the stripping motion of esophageal peristalsis
and the neutralizing bicarbonate in saliva?
Manometry will show a normal proximal (striated muscle) esophagus with low or absent distal esophageal peristalsis
and low LES pressure.
Patients with fundoplication (n = 4) had 45% of swallows followed by abnormal esophageal peristalsis
versus 17% in those without fundoplication (P < 0.
During the day, acid reflux stimulates increased secretion of saliva, which contains bicarbonate, and increased esophageal peristalsis
to help promote neutralization of acid and clear gastric refluxate.
Swallowing studies can be useful in evaluating nasopharyngeal reflux, aspiration, and esophageal peristalsis
The optimal treatment of the disease would improve esophageal peristalsis
and promote lower esophageal sphincter relaxation.