Eosinophilic esophagitis is a T-helper (Th) 2-type immune/antigen mediated or atopic chronic relapsing disease involving ingested and inhaled allergens with remodeling of the esophagus resulting in dense eosinophilic infiltrate, esophageal dysfunction
, and bolus impaction with majority of the patients having concurrent allergic rhinitis, asthma, eczema, and/or history of atopy.
Megaesophagus is an esophageal dysfunction
resulting from atony of the esophageal musculature characterized by flaccidity and luminal dilation, as a consequence of segmental or diffused motor dysfunction of the esophageal body (TORRES, 1997).
EoE patients may have persistent or relapsing symptoms related to esophageal dysfunction
, which include dysphagia (difficulty swallowing) and food impaction.
Inflammation of the esophagus, as seen in EoE patients, can eventually lead to debilitating esophageal dysfunction
, causing difficulty in swallowing, esophageal fibrosis, and food impaction.
A definitive diagnosis was made in 32 of 33 cases, making idiopathic esophageal dysfunction
The presenting sign suggested esophageal dysfunction
(caused by stiffening of the gastrointestinal tract muscles; gastroesophageal reflux, a form of indigestion, is a common result)
In two cases of esophageal dysfunction
with clozapine treatment, both patients had been treated with four typical antipsychotics at a minimum of 1,000 chlorpromazine equivalents (J.
1,7) It is believed that the primary defect in GERD is lower esophageal dysfunction
, whereas the primary defect in LPR might be upper esophageal sphincter dysfunction.
with rapidly growing mycobacterial infections has also been reported in patients with Parkinson disease, stroke, esophageal stricture, and after gastrectomy (as in our patient).
In one study, approximately half of the patients with a history of chest pain showed esophageal dysfunction
as the cause of their pain.