escitalopram oxalate

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escitalopram oxalate

Cipralex (UK), Lexapro

Pharmacologic class: Selective serotonin reuptake inhibitor

Therapeutic class: Antidepressant

Pregnancy risk category C


Prevents serotonin reuptake by CNS neurons, making more serotonin available in brain and thereby relieving depression


Oral solution: 5 mg/5 ml

Tablets: 5 mg, 10 mg, 20 mg

Indications and dosages

Major depression

Adults: Initially, 10 mg P.O. daily as a single dose. After at least 1 week, may increase to 20 mg P.O. daily, as needed.

Adolescents ages 12 to 17: Initially, 10 mg P.O. daily. After at least 3 weeks, may increase to 20 mg P.O. daily as needed.

Elderly adults and patients with hepatic impairment: Maximum dosage of 10 mg P.O. daily as a single dose

Generalized anxiety disorder

Adults: Initially, 10 mg P.O. daily as a single dose. After at least 1 week, may increase to 20 mg P.O. daily as needed.

Dosage adjustment

• Hepatic impairment

• Elderly patients


• Hypersensitivity to drug

• Concurrent use of pimozide

• MAO inhibitor use within past 14 days


Use cautiously in:

• renal or hepatic impairment, other conditions that cause altered metabolism or hemodynamic responses, history of mania or seizures, suicidal tendency

• concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, warfarin, or other drugs that affect coagulation

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 12 with major depression and younger than age 18 with generalized anxiety disorder (safety and efficacy not established).


• Give with or without food in the morning or evening.

Don't give within 14 days of MAO inhibitor.

Adverse reactions

CNS: drowsiness, dizziness, insomnia, fatigue, neuroleptic malignant syndrome-like reactions, increased risk of suicide or suicidal ideation (especially in child or adolescent)

EENT: rhinitis, sinusitis

GI: nausea, vomiting, diarrhea, constipation, dyspepsia, abdominal pain, dry mouth

GU: ejaculatory disorders, erectile dysfunction, anorgasmia (in females), decreased libido

Metabolic: hyponatremia (in association with syndrome of inappropriate antidiuretic hormone secretion)

Other: increased appetite, flulike symptoms, serotonin syndrome


Drug-drug. Aspirin, NSAIDs, warfarin: increased risk of bleeding

Carbamazepine, lithium: decreased effects of escitalopram

Citalopram: increased risk of serious toxic effects

MAO inhibitors: increased escitalopram blood level and risk of toxicity

Pimozide: prolonged QT interval

Triptans: weakness, hyperreflexia, incoordination

Drug-diagnostic tests. Sodium: decreased level

Drug-herbs. Ginkgo, St. John's wort: increased risk of adverse effects

Drug-behaviors. Alcohol use: increased motor impairment

Patient monitoring

Assess patient's mood closely. Watch for signs and symptoms of increased depression or suicidal ideation (especially in child or adolescent).

Monitor patient closely for serotonin syndrome or neuroleptic malignant syndrome-like reactions; immediately discontinue drug if these occur.

• Be aware that gradual dosage reduction rather than abrupt cessation is recommended. When drug is discontinued, monitor for dysphoric mood, irritability, agitation, dizziness, sensory disturbances, anxiety, confusion, headache, lethargy, emotional lability, and insomnia.

Patient teaching

• Advise patient to minimize GI upset by eating small, frequent servings of food and drinking plenty of fluids.

• Inform patient that full drug effect may take up to 4 weeks. Caution him not to overuse drug or stop drug abruptly.

Tell patient (and parent or significant other as appropriate) to contact prescriber immediately if depression worsens or suicidal thoughts develop (especially in child or adolescent).

Instruct patient to immediately discontinue drug and notify prescriber if the following symptoms occur: overheating, muscle rigidity, altered mental status, irregular pulse or blood pressure, rapid or irregular heart beat, excessive sweating, involuntary muscle movements, fever, or seizures.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

escitalopram oxalate

Lexapro® Neurology A serotonin reuptake inhibitor-type antidepressant, an isomer of citalopram Adverse events N&V, insomnia, ejaculation disorder, diaphoresis, fatigue
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Escitalopram oxalate

Lexapro; a SSRI that is very similar to Celexa but contains only the active chemical form.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The company said that Escitalopram Oxalate Tablets are the generic version of Forest Laboratories' Lexapro Tablets.
Persons Reporting Prescriptions for 10 Leading Psychiatric Drugs (a) Drug Name Mechanism Rank (Brand Name) of Action 1 Sertraline hydrochlolride SSRI (Zoloft) antidepressant 2 Citalopram hydrobromide SSRI (Celexa) antidepressant 3 Alprazolam (Xanax) Benzodiazepine 4 Zolpidem tartrate (Ambien) Hypnotic 5 Fluoxetine hydrochloride SSRI (Prozac) antidepressant 6 Trazodone hydrochloride SARI (Desyrel) antidepressant 7 Clonazepam (Klonopin) Benzodiazepine 8 Lorazepam (Ativan) Benzodiazepine 9 Escitalopram oxalate SSRI (Lexapro) antidepressant 10 Duloxetine hydrochloride SNRI (Cymbalta) antidepressant Reported Use, Prescriptions per Rank No.
68 Escitalopram Oxalate Accord 16729016901 5,293,433
Escitalopram oxalate tablets, 5 mg, Alphapharm Pty.
Escitalopram oxalate tablets, 5 mg, Teva Pharmaceuticals 7/26/2006
The recommended dose of the product, known by its generic name of escitalopram oxalate, is 10 mg.