escape mutation


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escape mutation

The ability of a microorganism to defend itself from host immune responses by making mutations in its genotype and phenotype. Organisms with a high rate of mutations, e.g., human immunodeficiency virus, rely on mutational escape as one mechanism to avoid destruction by host cells.
Synonym: mutational escape
See also: mutation
References in periodicals archive ?
By using a chimeric antigen with 17 distinct antigenic targets (epitopes) in a single, vaccine, the authors reported that escape mutations which would allow tumors to escape immune attack did not occur.
Escape mutations can develop over time and prevent an immunotherapy from working.