erythromelalgia


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e·ryth·ro·mel·al·gi·a

(ĕ-rith'rō-mel-al'jē-ă),
1. A rare disorder most common in middle age, characterized by paroxysmal attacks of severe burning pain, reddening, hyperalgesia, and sweating, involving one or more extremities, usually both feet; the attacks can be triggered by warmth, but are usually relieved by cold and limb elevation.
2. Paroxysmal throbbing and burning pain in the skin often precipitated by exertion or heat, affecting the hands and feet, accompanied by a dusky mottled redness of the parts with increased skin temperature; associated with and often preceding myeloproliferative and other disorders.
[erythro- + G. melos, limb, + algos, pain]

e·ryth·ro·mel·al·gi·a

(ĕ-rith'rō-mel-al'jē-ă)
1. Paroxysmal throbbing and burning pain in the skin often precipitated by exertion or heat, affecting the hands and feet, accompanied by a dusky mottled redness of the parts with increased skin temperature; may be associated with myeloproliferative disorders.
2. A rare disorder of middle age, characterized by paroxysmal attacks of severe burning pain, reddening, hyperalgesia, and sweating, involving one or more extremities, usually both feet; the attacks can be triggered by warmth, and are usually relieved by cold and limb elevation.
Synonym(s): Mitchell disease, red neuralgia.
[erythro- + G. melos, limb, + algos, pain]

erythromelalgia

Mottled redness and a painful burning sensation in the extremities, usually the feet, with a local rise in skin temperature.

Gerhardt,

Carl Adolf Christian Jacob, German physician, 1833-1902.
Gerhardt disease - Synonym(s): Gerhardt-Mitchell disease
Gerhardt-Mitchell disease - paroxysmal throbbing and burning pain in the skin affecting the hands and feet, accompanied by a dusky mottled redness of the parts with increased skin temperature. Synonym(s): erythromelalgia; Gerhardt disease; Mitchell disease; Weir Mitchell disease
Gerhardt reaction - Synonym(s): Gerhardt test for acetoacetic acid
Gerhardt-Semon law - obsolete law formerly used to account for the position of affected vocal cords after injury to the recurrent laryngeal nerve(s).
Gerhardt sign - complete bilateral paralysis of the adductor muscles of the larynx with severe inspiratory dyspnea. Synonym(s): Biermer sign
Gerhardt syndrome - bilateral laryngeal abductor paralysis.
Gerhardt test for acetoacetic acid - Synonym(s): Gerhardt reaction
References in periodicals archive ?
In a Chinese study this symptom was present in 17% of the patients.6 Facial plethora was present in 100% of our patients while in another study it was present in 54% of the patients5.Among different signs, erythromelalgia was most common.
It is concluded that the most frequent symptoms in patients with polycythemia are erythromelalgia, facial plethora and headaches.
Historically, erythromelalgia has been thought to be a rare condition but recent evidence indicates that it is probably more common than was once believed and that there is a spectrum of symptom experiences from trivial distress to limb-threatening disease [5, 23].
Lewis, "Clinical observations and experiments relating to burning pain in the extremities, and to so-called "erythromelalgia" in particular," Clinical Science, vol.
Thermoregulatory sweat testing and other neurologic evaluations of 32 erythromelalgia patients showed that people with the syndrome do not sweat in all or part of their bodies, he reported.
A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity.
One set of gain-of-function mutations produces erythromelalgia or the "man-on-fire" syndrome in which dysfunctional Nav1.7 channels cause nociceptors to fire at the merest hint of provocation and stay provoked for an abnormal length of time (Dib-Hajj, S.D., et al., 2005).
* Erythromelalgia. Children complain of hot, tingling, burning pain of both feet and perhaps the hands as well.
Miscellaneous Kasabach-Merritt phenomenon Purpura fulminans Kawasaki disease Sclerema neonatorum Erythromelalgia Other
The new wing will house the Yale Center's ongoing pain studies in patients with an inherited pain syndrome known as erythromelalgia or "man on fire" syndrome.
Francis described erythromelalgia is a "mysterious condition" in which an increase in blood flow and temperature in the extremities strangely corresponds to a decrease in tissue oxygenation due to dysfunctions of the precapillary sphincters and arteriovenous shunts, said Dr.
Waxman's team uncovered the cause of a rare inherited pain syndrome called erythromelalgia, which causes intense burning pain, often in the hands and feet, that is triggered by seemingly simple stimuli such as clothing, warm temperatures, and light exercise.