erythroleukemia


Also found in: Dictionary, Wikipedia.

erythroleukemia

 [ĕ-rith″ro-loo-ke´me-ah]
a malignant blood dyscrasia, one of the myeloproliferative disorders, with atypical erythroblasts and myeloblasts in the peripheral blood.
acute erythroleukemia a form of acute myelogenous leukemia representing erythroleukemia in which malignant leukocyte precursors have proliferated and become predominant.

e·ryth·ro·leu·ke·mi·a

(ĕ-rith'rō-lū-kē'mē-ă),
Simultaneous neoplastic proliferation of erythroblastic and leukoblastic tissues.

erythroleukemia

Di Guglielmo syndrome Hematology An acute myelocytic leukemia–FAB classification, M6, which is usually acquired affecting the elderly, but rarely also AD Clinical Anemia, fever, hepatosplenomegaly, hemorrhagic diathesis Lab ↑ Erythroblasts in circulation, BM, ↑ gammaglobulins, false positive positive rheumatoid factor, ANA, Coombs antiglobulin Genetics Aneuploidy–63%; cytogenetic defects, especially chromosomes 5 and 7 Prognosis Poor. See French-American-British classification.

e·ryth·ro·leu·ke·mi·a

(ĕ-rith'rō-lū-kē'mē-ă)
Simultaneous neoplastic proliferation of erythroblastic and leukoblastic tissues.
Synonym(s): erythroleukaemia.
References in periodicals archive ?
Jean et al., "Diosgenin dose-dependent apoptosis and differentiation induction in human erythroleukemia cell line and sedimentation field-flow fractionation monitoring," Analytical Biochemistry, vol.
Sonic Hedgehog activation is implicated in diosgenin-induced megakaryocytic differentiation of human erythroleukemia cells.
Nevertheless, in mouse erythroleukemia cells, experimental findings have suggested that activation of JNK is crucial for erythropoietin-induced erythroid differentiation [86, 88].
Erneux, "SHIP2 overexpression strongly reduces the proliferation rate of K562 erythroleukemia cell line," Biochemical and Biophysical Research Communications, vol.
Slobin, "Regulation of the utilization of mRNA for eucaryotic elongation factor Tu in Friend erythroleukemia cells," Molecular and Cellular Biology, vol.
reported that expression of GATA and KLF is significantly downregulated by SAHA treatment in human erythroleukemia cells [38].
Effects of trichostatins on differentiation of murine erythroleukemia cells.
Whilst HDACi were originally discovered by their ability to induce erythroid differentiation of erythroleukemia cells [11,12], the subsequent use of HDACi in cancer therapy has concentrated on its functions as a cytotoxic agent.
We and others have shown that alantolactone significantly increased the expression of p53 in HepG2 cells [50, 51] with concomitant increase of its downstream target, the cyclin-dependent kinase inhibitor p21 in adriamycin (ADR) resistant human erythroleukemia cell line K562/ADR [57].
Relationship correlation of antioxidant and antiproliferative capacity of Cyperus rotundus products towards K562 erythroleukemia cells.