19) The coexistent peripheral destruction along with central aplasia of the erythroid cell
line might result in serious anemia.
The team has now developed a robust and reproducible technique that allows the production of immortalized erythroid cell
lines from adult stem cells.
There are findings suggested that in primary erythroid cell
cultures, cAMP response element binding protein (CREB) is activated by cAMP-activated protein kinase A instead of p38 MAPK pathway.
Through the late 1980s, binding studies with radiolabeled erythropoietin in both mouse and human erythroid cell
lines suggested that receptor sites were present on erythropoietin-responsive RBC precursor cells (Jones, D'Andrea, Haines, & Wong, 1990).
Erythropoietin is a glycoprotein hormone that regulates erythroid cell
proliferation in bone marrow response to tissue hypoxia.
Since the receptor for B19 is blood group 'P' antigen (tetrahexose ceramide), it has great tropism for erythroid cell
precursors in the bone marrow.
Of note was the concurrent moderate decrease in PCV (30%, down from previous measurement of 40%) indicating that the erythroid cell
line was also affected.
series was depleted in 3 cases but was hyperplastic in 2 cases whereas megakaryocytic cell series was increased in all the 5 cases.
The bone marrow in CNL is hypercellular and myeloid, and usually has an myeloid to erythroid cell
ratio that varies between 5:1 and 25:1 (normal ratios are 2:1 to 5:1).
Bone marrow biopsy showed evidence of moderate hyperplasia of the erythroid cell
line (Figure 2).
The KG-1a, Kasumi-1, THP-1, U-937, and HL60 human myeloid lines; the Raji and Daudi B-cell lines; the Jurkat and CCRF-CEM T-cell lines; and the K562 and UT7 erythroid cell
lines were obtained from the cell bank of Tohoku University.