erythroblastic


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erythroblast

(e-rith'ro-blast) [? + blastos, germ] Normoblast.erythroblastic (-blas'tik), adjective
References in periodicals archive ?
Abnormalities of band-3 protein are associated with disease, such as hereditary spherocytosis and hereditary erythroblastic multinuclearity with a positive acidified serum test (HAMPAS) [30].
(8) Human genes: ERBB2 (also known as HER2), v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; EML4, echinoderm microtubule associated protein like 4; ALK, anaplastic lymphoma receptor tyrosine kinase; BRAF, B-Raf proto-oncogene, serine/threonine kinase; EGFR, epidermal growth factor receptor.
[6] Human genes: PTPRC, protein tyrosine phosphatase, receptor type, C; EPCAM, epithelial cell adhesion molecule; MUC1, mucin 1, cell surface associated; ERBB2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, (HER2); AKT2, v-akt murine thymoma viral oncogene homolog 2; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; TWIST1, twist family bHLH transcription factor 1; ALHD1A1, aldehyde dehydrogenase 1 family, member A1.
We designed highly purified salt-free OliGold primers (Eurogentec, Seraing, Belgium) for the internal control gene hypoxanthine phosphoribosyhransferase 1 (HPRT1) and for target genes estrogen receptor-[alpha] (ESR1), progesterone receptor (PGR), PDZ domain containing 1 (PDZK1), and erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2) using Roche Lightcycler software (Roche Diagnostics Belgium, Vilvoorde, Belgium).
(34) Myeloid to erythroid ratio, as a specific element, received the least attention in the literature reviewed, with its relevance stated specifically only in chronic MPN, (34) although, by expert panel consensus, erythroid enumeration is also relevant to current diagnosis and classification of specific subtypes of AML, such as acute erythroblastic leukemia.
Recently, substantial progress has been made in the discovery of new biomarkers, such as activating mutations in the epidermal growth factor receptor (EGFR) [2] and the kirsten rat sarcoma viral oncogene homolog (KRAS) gene and amplification of the v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) and the echinoderm microtubule-associated protein like 4--anaplastic lymphoma receptor tyrosine kinase (EML4--ALK) fusion gene.
For example, evaluation of the status of the v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2, formerly HER2/ Neu) status can stratify subsets of breast cancer patients who are likely to respond to trastuzumab.
Other significantly mutated single genes reported in TNBC include: USH2A, myosin IIIA (MYO3A), PTEN, retinoblastoma 1 (RB1), ataxia telangiectasia and Rad3 related (ATR), ubiquitin protein ligase E3 component n-recognin 1 (UBR1), collagen, type VI, alpha 3 (COL6A3), and several well-known oncogenes [v-raf murine sarcoma viral oncogene homolog B (BRAF), neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS), v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), and v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3)] (18,42,58).
Increased amounts of the cell cycle proteins cyclin E and p16, amplification and overexpression of the ERBB2 [v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2] gene (which encodes the ERBB2 receptor tyrosine kinase), loss of BAF250A production, and altered amounts of the cell adhesion proteins claudin-3, claudin-4, L1CAM (L1 cell adhesion molecule), EpCAM (epithelial cell adhesion molecule), and E-cadherin have also been documented [reviewed in (24)].
The quantitative ability of dPCR has already been applied to monitoring viral load (14) and measuring copy number variations in HER2 (ERBB2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) gene status in breast cancer (15).
Erythroblastic leukemia viral oncogene homolog 2 (ERBB2) is amplified in ~2% of NSCLCs, (17,18) and mutated in ~2% of NSCLCs, (18-20) though it is overexpressed in about 20% of cases.