erythema nodosum leprosum


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er·y·the·ma no·do·sum le·pro·sum

an acute type of lepromatous reaction with generalized systemic involvement and tender deep cutaneous and subcutaneous nodules of the face, thighs, and arms; usually seen in undiagnosed, untreated, or neglected cases of leprosy. Immune complexes and scanty, fragmented lepra bacilli may be seen in the lesions.

er·y·the·ma no·do·sum le·pro·sum

(er-i-thēmă nō-dōsŭm lep-rōsŭm)
Acute type of lepromatous reaction with generalized systemic involvement and tender deep cutaneous and subcutaneous nodules of the face, thighs, and arms; usually seen in undiagnosed, untreated, or neglected cases of leprosy.

erythema nodosum leprosum

Abbreviation: ENL
A red, nodular vasculitic rash, which may be a complication of the treatment for leprosy. See: lepra

Treatment

Treatment consists of withdrawing therapy against leprosy (clofazimine, steroids, thalidomide).

See also: erythema
References in periodicals archive ?
Erythema nodosum leprosum in Nepal: a retrospective study of clinical features and response to treatment with prednisolone or thalidomide.
67%), erythema nodosum leprosum (20%), cutaneous tuberculosis and trichoepithelioma (8% each), Prurigo Nodularis, actinomycosis and epidermoid cyst (6.
Guidelines for the management of severe erythema nodosum leprosum (ENL) reactions.
9% had already had some kind of reactional episode such as erythema nodosum leprosum (ENH) and/or reversal reactions (RR).
We frequently publish Case Reports describing unusual manifestations or complications of Type 2 leprosy reactions, also known as Erythema Nodosum Leprosum (ENL), and this issue of Leprosy Review is no exception.
Food and Drug Administration (FDA) for thalidomide in the treatment of the cutaneous manifestations of erythema nodosum leprosum (ENL), a severe and debilitating condition associated with leprosy.
Erythema Nodosum Leprosum (ENL, Type 2 leprosy reaction) is a severe multi-system disorder characterised by tender crops of cutaneous lesions, neuritis, fever and inflammation of the joints, testes, eyes and bones.
Type 2 lepra reactions, and its cutaneous manifestation, Erythema Nodosum Leprosum (ENL) are an immune complex mediated systemic condition, often complicating the disease and/or its treatment in cases of the lepromatous spectrum of leprosy.
The slit skin smear was positive and histopathology of the skin from lesions showed ulcerated stratified squamous epithelium, intraepidermal bulla, foamy macrophages with a few giant cells in the dermis, vasculitis with perivascular neutrophilic and lymphocytic infiltration along with dense infiltration of neutrophils in the dermis and subcutaneous fat (septal panniculitis) consistent with features of erythema nodosum leprosum (Figure 2).
4) We describe a patient with erythema nodosum leprosum misdiagnosed as systemic lupus erythematosus, who upon treatment for leprosy developed hemophagocytic lymphohistiocytosis.
He continued to get new lesions of leprosy and recurrent erythema nodosum leprosum (ENL).
In 2006 he developed erythema nodosum leprosum and was treated successfully with a short period of prednisone together with thalidomide 100 mg/day that he was still continuing.