erythema nodosum leprosum


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er·y·the·ma no·do·sum le·pro·sum

an acute type of lepromatous reaction with generalized systemic involvement and tender deep cutaneous and subcutaneous nodules of the face, thighs, and arms; usually seen in undiagnosed, untreated, or neglected cases of leprosy. Immune complexes and scanty, fragmented lepra bacilli may be seen in the lesions.

er·y·the·ma no·do·sum le·pro·sum

(er-i-thēmă nō-dōsŭm lep-rōsŭm)
Acute type of lepromatous reaction with generalized systemic involvement and tender deep cutaneous and subcutaneous nodules of the face, thighs, and arms; usually seen in undiagnosed, untreated, or neglected cases of leprosy.

erythema nodosum leprosum

Abbreviation: ENL
A red, nodular vasculitic rash, which may be a complication of the treatment for leprosy. See: lepra

Treatment

Treatment consists of withdrawing therapy against leprosy (clofazimine, steroids, thalidomide).

See also: erythema
References in periodicals archive ?
A rare variant of erythema nodosum leprosum: a case report.
Erythema Nodosum Leprosum International Study Group: 3rd ENLIST Meeting Report, Mumbai, 7th-9th April 2015.
Lesions like leprosy, erythema nodosum leprosum, trichoepithelioma, Metastatic carcinoma were more common in males, while Prurigo Nodularis and granuloma annulare were more common in females.
IgM anti-phenolic glycolipid I and IgG anti 10-kDp a heat shock protein antibody in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts.
[5.] Dave S, Thappa DM, Nove AV, Jayanthi S: A rare variant of erythema nodosum leprosum: a case report.
At the time of interview, none of the interviewees had any other leprosy-related complications, but 72.9% had already had some kind of reactional episode such as erythema nodosum leprosum (ENH) and/or reversal reactions (RR).
We frequently publish Case Reports describing unusual manifestations or complications of Type 2 leprosy reactions, also known as Erythema Nodosum Leprosum (ENL), and this issue of Leprosy Review is no exception.
Erythema Nodosum Leprosum (ENL, Type 2 leprosy reaction) is a severe multi-system disorder characterised by tender crops of cutaneous lesions, neuritis, fever and inflammation of the joints, testes, eyes and bones.
Keywords: type 2 lepra reaction, erythema nodosum leprosum, thalidomide, methotrexate, resistant, treatment, prednisolone, leprosy, Hansen disease
The slit skin smear was positive and histopathology of the skin from lesions showed ulcerated stratified squamous epithelium, intraepidermal bulla, foamy macrophages with a few giant cells in the dermis, vasculitis with perivascular neutrophilic and lymphocytic infiltration along with dense infiltration of neutrophils in the dermis and subcutaneous fat (septal panniculitis) consistent with features of erythema nodosum leprosum (Figure 2).
(4) We describe a patient with erythema nodosum leprosum misdiagnosed as systemic lupus erythematosus, who upon treatment for leprosy developed hemophagocytic lymphohistiocytosis.
He continued to get new lesions of leprosy and recurrent erythema nodosum leprosum (ENL).