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a vasoconstrictor that binds to several receptor populations (e.g., alpha-adrenergic, dopamine, serotonin) and, depending upon the receptor, can be an agonist or antagonist.
indications It is prescribed to abort or prevent vascular headaches such as migraines.
contraindications Pregnancy, peripheral vascular disease, infectious disease, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects are vomiting, diarrhea, thirst, tingling of fingers and toes, and increased blood pressure. Fetal death may occur if it is used during pregnancy.
A white crystalline substance that stimulates smooth muscle of blood vessels and the uterus, inducing vasoconstriction and uterine contractions. It is used in the treatment of migraine. Trade names are Ergomar, Ergostat, and Gynergen.
See also: ergotamine