ergotamine


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Related to ergotamine: Dihydroergotamine

ergotamine

 [er-got´ah-min]
an alkaloid derived from ergot, used as the tartrate salt in treatment of migraine and cluster headaches; administered orally, sublingually, rectally, or by oral inhalation.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

er·got·a·mine

(er-got'ă-mēn),
An alkaloid from ergot, used to relieve migraine; it is a potent stimulant of smooth muscle, particularly of the blood vessels and the uterus, and produces adrenergic blockade (chiefly of the alpha receptors); hydrogenated ergotamine, dihydroergotamine, is less toxic and has fewer side effects. Also available as ergotamine tartrate.
Farlex Partner Medical Dictionary © Farlex 2012

ergotamine

(ûr-gŏt′ə-mēn′, -mĭn)
n.
A crystalline alkaloid, C33H35N5O5, derived from ergot that induces vasoconstriction and is used especially in treating migraine.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

er·got·a·mine

(er-got'ă-mēn)
An alkaloid from ergot, used to relieve migraine; it is a potent stimulant of smooth muscle, particularly of the blood vessels and the uterus, and produces adrenergic blockade (chiefly of the alpha receptors); hydrogenated ergotamine, dihydroergotamine, is less toxic and has fewer side effects. Also available as ergotamine tartrate.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Ergotamine

A drug used to prevent or treat migraine headaches. This can cause vomiting, diarrhea, and convulsions in infants.
Mentioned in: Lactation
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

er·got·a·mine

(er-got'ă-mēn)
An alkaloid from ergot, used to relieve migraine.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Compound % cross-reactivity 6-nor-LSD 52 Lysergic acid methyl-n-propyl amide (LAMPA) 34 2-oxo-3-hydroxy-LSD 3.4 iso-LSD 0.05 Ergonovine 0.016 Methylergonovine 0.008 D-Lysergic acid, lysergic acid amide Ergotamine, dihydroergotamine Methysergide, lysergol No cross-reactivity [alpha]-Ergocryptine, ergocristine Ergocornine, N,N-dimethyltryptamine (<0.008%) 5-Hydroxytryptamine, mescaline Psilocin, L-tryptophan Hordenine, coramine Gramine, L-amphetamine The degree of cross-reactivity was calculated from the concentration of substance that produced a decrease in signal that was equivalent to 0.5 [micro] g/L LSD.
Under the microscope, however, valve tissue from these patients looked virtually identical to valve tissue damaged 6y ergotamine poisoning or a rare cancer in which high concentrations of serotonin are thought to injure heart valves.
Sumatriptan should not be combined with ergotamine or dihydroergotamine.
Group Dose CGRP NO(|xmol/l) F.T(PG/mi) ET/NO (mg/kg) (PC/ml) Control - 160.16[+ or 23.04 [+ or 117.09 [+ 5.07 [+ -] 28.58 -] 3.50 or -] or -] 21.20 0.65 Model - 213.41 [+ 126.73 [+ or 113.82 [+ 0.92 or -] -] 18.03 ## or -] 9.10 -0.16 ** 15.22 ## Ergotamine 1.00 87.45 [+ or 72.57 [+ or 143.16 [+ 1.72 -t -] 21.36 ** -] 6.72 ** or -] 0.31 ** 13.13 ** 108.00 99.86 + 71.71 [+ or 152.88 [+ 2.16 + 23.27 ** -] 8.76 ** or 0.33 ** -] 9.39 ** TFY 54.00 81.25 [+ or 89.68 [+ or 146.48 [+ 1.63 + -] 18.76 ** -] 6.34 ** or -] 0.22 ** 23.23 ** 27.00 98.15 [+ or 96.31 [+ or 132.90 [+ 1.39 [+ -]20.20 ** -] 10.79 ** or -] or -] 8.27** 0.17 ** Data were presented as mean [+ or -] SD, (n = 10).
There are currently five approved ergotamine-containing drugs: Migergot suppositories (marketed by G & W Laboratories Inc.), ergotamine tartrate and caffeine tablets (marketed by West-Ward Pharmaceutical Corporation and Mikart), Cafergot tablets (marketed by Sandoz), and Ergo-mar sublingual tablets (marketed by Rosedale Therapeutics).
It also requires a No Objection Certificate for the import of acetic anhydride, ergotamine and piperonal.
Medications like triptans, anti-emetics, varapamil, nonsteroidal anti-inflammatory drugs (NSAIDs), anticonvulsants, prednisone and ergotamine are also helpful.
Another drug that provides relief of migraine symptoms is ergotamine tartrate, a drug that constricts blood vessels, helping to counteract the painful blood dilation stage of the headache.
Because ergotamine tartrate and dihydroergotamine (DHE) can cause nausea and vomiting, they may be combined with anti-nausea drugs.
45), ergotamine (Ergomar) (alone or in combination with caffeine, or caffeine-belladonna-pentobarbital), intranasal lidocaine, and selective serotonin receptor agonists, also called triptans.
Ergovaline was determined as the sum of ergovaline and ergovalinine (regarded as a more stable and repeatable measure, Lane, 1999), detected by fluorescence after reversed phase HPLC and compared to an ergotamine internal standard added to each sample.