Compound % cross-reactivity 6-nor-LSD 52 Lysergic acid methyl-n-propyl amide (LAMPA) 34 2-oxo-3-hydroxy-LSD 3.4 iso-LSD 0.05 Ergonovine 0.016 Methylergonovine 0.008 D-Lysergic acid, lysergic acid amide Ergotamine
, dihydroergotamine Methysergide, lysergol No cross-reactivity [alpha]-Ergocryptine, ergocristine Ergocornine, N,N-dimethyltryptamine (<0.008%) 5-Hydroxytryptamine, mescaline Psilocin, L-tryptophan Hordenine, coramine Gramine, L-amphetamine The degree of cross-reactivity was calculated from the concentration of substance that produced a decrease in signal that was equivalent to 0.5 [micro] g/L LSD.
Under the microscope, however, valve tissue from these patients looked virtually identical to valve tissue damaged 6y ergotamine
poisoning or a rare cancer in which high concentrations of serotonin are thought to injure heart valves.
Sumatriptan should not be combined with ergotamine
Group Dose CGRP NO(|xmol/l) F.T(PG/mi) ET/NO (mg/kg) (PC/ml) Control - 160.16[+ or 23.04 [+ or 117.09 [+ 5.07 [+ -] 28.58 -] 3.50 or -] or -] 21.20 0.65 Model - 213.41 [+ 126.73 [+ or 113.82 [+ 0.92 or -] -] 18.03 ## or -] 9.10 -0.16 ** 15.22 ## Ergotamine
1.00 87.45 [+ or 72.57 [+ or 143.16 [+ 1.72 -t -] 21.36 ** -] 6.72 ** or -] 0.31 ** 13.13 ** 108.00 99.86 + 71.71 [+ or 152.88 [+ 2.16 + 23.27 ** -] 8.76 ** or 0.33 ** -] 9.39 ** TFY 54.00 81.25 [+ or 89.68 [+ or 146.48 [+ 1.63 + -] 18.76 ** -] 6.34 ** or -] 0.22 ** 23.23 ** 27.00 98.15 [+ or 96.31 [+ or 132.90 [+ 1.39 [+ -]20.20 ** -] 10.79 ** or -] or -] 8.27** 0.17 ** Data were presented as mean [+ or -] SD, (n = 10).
If they are ineffective, proceed to an ergotamine
There are currently five approved ergotamine-containing drugs: Migergot suppositories (marketed by G & W Laboratories Inc.), ergotamine
tartrate and caffeine tablets (marketed by West-Ward Pharmaceutical Corporation and Mikart), Cafergot tablets (marketed by Sandoz), and Ergo-mar sublingual tablets (marketed by Rosedale Therapeutics).
It also requires a No Objection Certificate for the import of acetic anhydride, ergotamine
Medications like triptans, anti-emetics, varapamil, nonsteroidal anti-inflammatory drugs (NSAIDs), anticonvulsants, prednisone and ergotamine
are also helpful.
Another drug that provides relief of migraine symptoms is ergotamine
tartrate, a drug that constricts blood vessels, helping to counteract the painful blood dilation stage of the headache.
tartrate and dihydroergotamine (DHE) can cause nausea and vomiting, they may be combined with anti-nausea drugs.
(Ergomar) (alone or in combination with caffeine, or caffeine-belladonna-pentobarbital), intranasal lidocaine, and selective serotonin receptor agonists, also called triptans.
Ergovaline was determined as the sum of ergovaline and ergovalinine (regarded as a more stable and repeatable measure, Lane, 1999), detected by fluorescence after reversed phase HPLC and compared to an ergotamine
internal standard added to each sample.