erb-B2

erb-B2

(erb'be'too')
A member of the erb-B family of oncogenes. This oncogene is overexpressed in some cancers and is associated with progression of breast cancer. Its protein product contains part of the epidermal growth factor (EGF) receptor. Synonym: HER2 See: oncogene; epidermal growth factor; breast cancer
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The study revealed 44.4% of the samples to be erb-b2 amplified.
erb-b2 amplification by fluorescence in situ hybridization in breast cancer specimens read as 2+ in immunohistochemical analysis.
Serial sequencing of cfDNA could lead to the discovery of molecular resistance mechanisms and the identification of new therapeutic targets [for example, MET proto-oncogene, receptor tyrosine kinase (MET) and erb-b2 receptor tyrosine kinase 2 (ERBB2) amplification as a resistance mechanism to EGFR inhibition in metastatic colorectal cancer, and the acquisition of EGFR T790M mutation in lung cancers treated with early-generation EGFR tyrosine kinase inhibitors] (3).
[3] Human genes: IDH1, isocitrate dehydrogenase 1; IDH2, isocitrate dehydrogenase 2; MET, MET proto-oncogene, receptor tyrosine kinase; ERBB2, erb-b2 receptor tyrosine kinase 2; EGFR, epidermal growth factor receptor; TP53, tumor protein p53; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; KRAS, Kirsten rat sarcoma viral oncogene homolog; ALK, anaplastic lymphoma receptor tyrosine kinase; BRAF, b-raf proto-oncogene, serine/threonine kinase.
No correlation was observed between IHC results for ER and amplification levels of ErbB1 (r=0.069, p=0.716) and Erb-B2 (r=0.207, p=0.272) assessed by the HPLC method.
These tyrosine kinases are encoded by gene erb-B located on chromosome 17q21 [14] {erb-B1, erb-B2, erb-B3 & erb-B4}.
Although the clinical importance of EGFR amplification is controversial, other amplifications such as ERBB2 (erb-b2 receptor tyrosine kinase 2; formerly HER2) are diagnostically important.
These tyrosine kinases are encoded by gene Erb-B located on chromosome 17q21 [15] (Erb-B1, Erb-B2, Erb-B3 and Erb-B4).
EGFR exon 20 insertion mutations are mutually exclusive from other well-identified oncogenic driver mutations seen in lung adenocarcinoma [e.g., KRAS (Kirsten rat sarcoma viral oncogene homolog), ERBB2 (erb-b2 receptor tyrosine kinase 2), BRAF(B-Raf protooncogene, serine/threonine kinase), and ALK fusions] (4, 6).
We compared the erb-b2 receptor tyrosine kinase 2 (ERBB2) (Her2) copy number status measured in tumor samples by the T200 platform with those obtained from FISH (fluorescent in situ hybridization) or immunohistochemistry for the same samples.
Other markers are C-kit, C erb-b2 and intercellular adhesion molecule.
Presumably, these regions with increased melting temperatures, located in the vicinity of the p16 and Erb-B2 amplicons, are likely to make these targets susceptible to inaccurate quantification.