erb-B2

erb-B2

(erb'be'too')
A member of the erb-B family of oncogenes. This oncogene is overexpressed in some cancers and is associated with progression of breast cancer. Its protein product contains part of the epidermal growth factor (EGF) receptor. Synonym: HER2 See: oncogene; epidermal growth factor; breast cancer
References in periodicals archive ?
19] For the first time, HER-2 overexpression was described in carcinoma breast [20] and mechanism underlying this overexpression is amplification of erb-B2 gene.
Serial sequencing of cfDNA could lead to the discovery of molecular resistance mechanisms and the identification of new therapeutic targets [for example, MET proto-oncogene, receptor tyrosine kinase (MET) and erb-b2 receptor tyrosine kinase 2 (ERBB2) amplification as a resistance mechanism to EGFR inhibition in metastatic colorectal cancer, and the acquisition of EGFR T790M mutation in lung cancers treated with early-generation EGFR tyrosine kinase inhibitors] (3).
3] Human genes: IDH1, isocitrate dehydrogenase 1; IDH2, isocitrate dehydrogenase 2; MET, MET proto-oncogene, receptor tyrosine kinase; ERBB2, erb-b2 receptor tyrosine kinase 2; EGFR, epidermal growth factor receptor; TP53, tumor protein p53; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; KRAS, Kirsten rat sarcoma viral oncogene homolog; ALK, anaplastic lymphoma receptor tyrosine kinase; BRAF, b-raf proto-oncogene, serine/threonine kinase.
The overexpression of Erb-B2 protein occurs in breast cancers because of gene amplification.
These tyrosine kinases are encoded by gene Erb-B located on chromosome 17q21 [15] (Erb-B1, Erb-B2, Erb-B3 and Erb-B4).
20] For the first time, HER-2 overexpression was described in carcinoma breast [21] and mechanism underlying this overexpression is amplification of Erb-B2 gene.
5] Human genes: EGFR, epidermal growth factor receptor; ERBB2, erb-b2 receptortyrosine kinase 2.
4] Human genes: EGFR, epidermal growth factor receptor; TP53, tumor protein p53; ALK, anaplastic lymphoma receptor tyrosine kinase; KRAS, Kirsten ratsarcoma viral oncogene homolog; ERBB2, erb-b2 receptor tyrosine kinase 2; BRAF, B-Raf protooncogene, serine/ threonine kinase.
We compared the erb-b2 receptor tyrosine kinase 2 (ERBB2) (Her2) copy number status measured in tumor samples by the T200 platform with those obtained from FISH (fluorescent in situ hybridization) or immunohistochemistry for the same samples.
Other markers are C-kit, C erb-b2 and intercellular adhesion molecule.