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equivalence trialA clinical trial with the primary objective of showing that the response to two or more treatments differs by an amount that is clinically insignificant, which is usually demonstrated by showing that the true treatment difference lies between a lower and an upper equivalence margin of clinically acceptable differences.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
equivalence trialClinical trials A study–eg, COBALT, intended to circumvent the ethical dilemmas of comparing a new therapy to a placebo which is known to be less effective than a proven therapy, by running the new agent against a standard therapy. See Clinical trial, COBALT.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
A randomized clinical trial in which two distinct agents are compared head-to-head against each other, and sometimes, but not always, against an inert agent (a placebo) as well. If two agents work equally well, the treatment that is less expensive, better tolerated, or more easily administered, may be preferable to use.
A randomized clinical trial in which two distinct agents are compared with each other and sometimes with an inert agent (a placebo) as well. If two agents work equally well, the less expensive, better tolerated, or more easily administered one may be preferred.
See also: trial
Medical Dictionary, © 2009 Farlex and Partners