equianalgesic


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equianalgesic

 [e-kwe-an″al-je´zik]
approximately equal in ability to relieve pain; said of drugs, doses, or routes of administration. (See accompanying table.)
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The documents state: "In terms of efficacy, all oliceridine regimens met the primary endpoint in both pivotal Phase 3 studies, meeting FDA's efficacy requirement for approval." A summary section also states: "A HAL study demonstrated that oliceridine was associated with similar drug liking to equianalgesic doses of morphine.
For patients on oral or parenteral therapy, consider switching to an equianalgesic dose of a less-constipating opioid, such as transdermal fentanyl or oxycodone-naloxone combination therapy.
The equianalgesic doses for conversion to other opioids (milliequivalents of morphine) are very variable.
Alternatively, subjects score their pain (from 0 to 10, 0 being no pain and 10 being the worst possible pain) over time during hand immersion in cold water (the cold pressor test is similar to that of the cold withdrawal test in the macaques (Figure 1) [43].) PF-05105679 was as equianalgesic as the opioid analgesic oxycodone [91].
They concluded that equianalgesic dose of tramadol has much less effect on respiratory centre compared to morphine.
The ED visit at which time the patient underwent the CT scan was used as the reference for recording patient characteristics, which included: age, gender, serum creatinine, leukocyte count, cumulative intravenous fluid, cumulative equianalgesic oral morphine dose, total nonsteroidal anti-inflammatory drug (NSAID) dose (ketorolac), fever (temperature above 38[degrees]C), as well as treatment with medical expulsive therapy and antibiotics.
Total opiate consumption was converted into an oral morphine equianalgesic dose [16] and pooled for each of the three groups.
This process of switching to another opioid, also called opioid rotation, is complicated by the need for utilizing equianalgesic doses and must take into account the possibility of tolerance to the current opioid.
A 30 mg dose of ketorolac is equianalgesic to 10 mg of morphine.
To facilitate data analysis, analgesic agents were converted into equianalgesic doses of morphine (e.g., doses that would offer the equivalent amount of morphine; American Pain Society, 2003).