epoxide hydrolase


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epoxide hydrolase

This enzyme name was retired in 2006, as its activity is due to two different enzymes:
• EC 3.3.2.9 (microsomal epoxide hydrolase); and
• EC 3.3.2.10 (soluble epoxide hydrolase).
References in periodicals archive ?
The report provides a snapshot of the global therapeutic landscape for Soluble Epoxide Hydrolase (Epoxide Hydratase or Aryl Epoxide Hydrase or EC 3.
Soluble epoxide hydrolase (50 ng/ml) were mixed with the inhibitors, tanshinone IIA (final concentration 0-10 [micro]M), cryptotanshinone (final concentration 0-100 [micro]M) or salvianolic acid C (final concentration 0-100 [micro]M) and preincubed at 37[degrees]C for 5 min.
The researchers performed a series of experiments on mice to determine whether nitro fatty acids lower blood pressure in mice by inhibiting soluble epoxide hydrolase.
Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.
Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies.
Epidermis: a site of drug metabolism in neonatal rat skin: studies on cytochrome P-450 content and mixed function oxidase and epoxide hydrolase activity.
Examples of specific topics include the pharmacology of iron transport, the impact of soluble epoxide hydrolase and epoxyeicosanoids on human health, small molecule-based approaches to adult stem cell therapies, and unnatural amino acids as probes of ligand-receptor interactions and their conformational consequences.
De Berardinis V, Moulis C, Maurice M, Beaune P, Pessayre D, Pompon D, Loeper J (2000) Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes.
The rapidly growing list of polymorphic genes coding for xenobiotic-metabolizing enzymes includes various cytochrome P450s, flavin monooxygenases, epoxide hydrolase, NAD(P)H:quinone oxidoreductase, UDP-glucuronosyltransferases, N-acetyltransferases, glutathione-S-transferases, and paraoxonase.
Although LTX-diol identified as the peak II component isolated from ground corncob in this study is an auto-oxidation product of linoleic acid in animals, a cytosolic epoxide hydrolase can metabolize the epoxy fatty esters to their vicinol diols (Halankar et al.
The new study has revealed that analgesia mediated by inhibitors of the enzyme, soluble epoxide hydrolase (sEH), is dependent on a pain-mediating second messenger known as cyclic adenosinemonophosphate or cAMP.
epoxide hydrolase, alcohol dehydrogenase), and two esterases involved in the detoxification of organophosphate (OP) pesticides.