epitope


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.

determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ep·i·tope

(ep'i-tōp),
The simplest form of an antigenic determinant on a complex antigenic molecule, which can combine with antibody or T cell receptor.
[epi- + -tope]
Farlex Partner Medical Dictionary © Farlex 2012

epitope

(ĕp′ĭ-tōp′)
n.
A localized region on the surface of an antigen capable of eliciting an immune response and of combining with a specific antibody to counter that response.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

epitope

Any site on a biomolecule (antigenic determinant) which can evoke antibody formation. The minimum size of a molecule capable of evoking antibody formation is about 1 kD; if the molecule is smaller, as with haptens, it may evoke an immune response by associating with a carrier protein. Large non-polymeric molecules can have many epitopes. When the van der Waals surfaces of proteins are constructed by X-ray crystallography, epitopic sites appear to require prominently exposed regions—“hills” and “ridges” with surface rigidity. More flexible sites are less antigenic.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

epitope

Immunology Any site on a molecule–an antigenic determinant that can evoke antibody formation. See Idiotype, Immunogenicity.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

ep·i·tope

(ep'i-tōp)
The simplest form of an antigenic determinant, on a complex antigenic molecule, that can combine with antibody or T-cell receptor.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

epitope

An immunologically active discrete site on an ANTIGEN to which an ANTIBODY or a B or T cell receptor actually binds. See also LINEAR EPITOPE and CONFORMATIONAL EPITOPE.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

epitope

an antigenic determinant which interacts with an IMMUNOGLOBULIN or T-CELL receptor.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Markovitz's was that vaccination with DerG LEAPS conjugates of distinct PG epitopes alone or together were effective at modulating the inflammatory response and arresting the progression of arthritis.
Six promising peptides (R6), namely, Rv1986-P9, Rv1986-P15, Rv1986-P16, Rv1988-P4, Rv1988-P11, and Rv1983-P4 (all identified by epitopes screening) were pooled together to assess the TB diagnosis potential in patients with symptoms of tuberculosis.
Construction of the recombinant vaccine based on T-cell epitope encoding Der p1 and evaluation on its specific immunotherapy efficacy.
Bovines 44 ([B.sub.2]T) and 36 ([B.sub.4]T) elicited high levels of antibodies against virus (although animal 36 showed levels of neutralizing antibodies of 1.2) and developed high levels of IgA specific against virus in nasal secretions as well as a positive lymphoproliferative response not only against dendrimeric peptides but also against the epitope T 3A (21-40).
For prediction of the linear B-cell epitopes in the ACTTS protein primary amino acids sequence, BCPREDS server was used.
Our flow cytometry studies showed that concealing of [gamma]c epitope with IL-7 was immediately induced just within 1 minute and even at 4[degrees]C at which IL-7R[alpha] was not downregulated.
Physicochemical properties of the epitope include a molecular weight of 1622.8 Da with 230 atoms ([C.sub.75][H.sub.115][N.sub.17][O.sub.23]).
The most common causes of false-negative immunostaining are poor tissue fixation, antibodies too dilute or not properly optimized, and epitope retrieval method not optimized for individual antibodies.
Importantly, the results of Semenov and Katrukha suggest that use of valsartan/sacubitril may affect all currently available BNP assays, and may do so in a heterogeneous fashion: those BNP assays based on epitopes found in the more vulnerable regions of BNP (e.g., [Met.sub.4] - [Val.sub.5] or [Arg.sub.17] - [Ile.sub.18]) may report an increase in BNP different from that of assays based on less vulnerable regions.
Protein sequence was analyzed for the prediction of B-cell epitopes by ABCpred server using neural network (Saha et al., 2006).
Yu, "An introduction to epitope prediction methods and software," Reviews in Medical Virology, vol.
Epitope conservancy of the selected epitopes was tested using epitope conservancytool (http://tools.immuneepitope .org/tools/conservancy/iedb_input) available in IEDB analysis resource.