epithelial microcysts

microcysts, epithelial

Very small, round vesicles containing fluid and cellular debris observed on the surface of the cornea under slit-lamp examination in some types of corneal dystrophy and in wearers of extended wear contact lenses, due to chronic hypoxia. They appear to originate in the basal layer of the corneal epithelium as a result of cellular necrosis. They can be seen by slit-lamp examination using a magnification of at least ✕20. If caused by extended wear contact lenses, the patient should be advised to change to daily wear contact lenses of high oxygen transmissibility. Syn. microepithelial cysts.
References in periodicals archive ?
Comparing the "success" and "failure" groups (Table 4), the area and density of epithelial microcysts were higher in success group but without reaching statistical significance (p > 0.05).
Different hypotheses on epithelial microcysts have been drawn; they are supposed to be hallmarks of transcleral and transconjunctival aqueous percolation or the result of an epithelial disruption, in particular a degeneration at goblet cells level [15].
Grade 3/4 treatment emergent adverse events (TEAEs) (>1 patient) were keratitis (15%), corneal epithelial microcysts (8%), hemiparesis (6%), hyperglycemia (6%), muscular weakness (6%), seizure (6%), blurred vision (4%) and ulcerative keratitis (4%).The most common TEAEs (?25% patients) in this study arm were blurred vision (60%), headache (29%), photophobia (29%), dry eye (27%), eye pain (27%), and fatigue (27%).
A history of previous trauma to the eye, recurrent episodes of pain on waking, family history of RCES and epithelial microcysts make diagnosis straightforward.
Epithelial microcysts with degeneration of basal epithelial cells are associated with the use of cytarabine16.
Ophthalmologic consultation showed bilateral multiple diffuse corneal epithelial microcysts and mild superficial punctate epitheliopathy (Figure 1).
Systemic use at high doses may also produce corneal and conjunctival epithelial toxicity, with conjunctival hyperemia, punctate keratopathy, and corneal epithelial microcysts (4).
Epithelial oedema characterises the third stage and fine epithelial microcysts are noted with irregular surface texture observed on sclerotic scatter.
In patients with (ABMD) and a history of RCES, the HRT II RCM showed an abnormal epithelial basement membrane protruding forward into the corneal epithelium, the presence of epithelial microcysts and normal superficial epithelial cells and stroma.
In patients with a history of previous trauma to the involved eye, episodes of pain on awakening, and epithelial microcysts, the diagnosis constitutes minimal clinical challenge.