epiregulin


Also found in: Wikipedia.

epiregulin

A member of the epidermal growth family which is encoded by EREG  on chromosome 4q13.3. It is a ligand of the EGF receptor (EGFR) and ERBB4; it may mediate localised cell proliferation, and may stimulate cell proliferation and/or angiogenesis.

epiregulin

(ep″ē-reg′yŭ-lin)
When released by a cell, an epidermal growth factor that stimulates the cell itself and other cells similar in structure and function to it. It is released in excessive quantities by cancerous cells and fosters their growth and spread throughout the body.
Mentioned in ?
References in periodicals archive ?
Moreover, the interactions between KDM2A and BCOR can inhibit osteogenesis by suppressing epiregulin (EREG) gene transcription, which is required for the expression of osterix (OSX) and distalless homeobox 5 (DLX5) [52].
Insulin-like growth factor (IGF-I) has shown promise in animal models and early human studies, promoting cumulus cell expansion [52], and recombinant epidermal growth factor has been added with success to some culture systems [53] as well as its family members amphiregulin and epiregulin showing promise in terms of maturation rates and embryo developmental capacity to the day two to three stage [54].
ADAM17 works in association with the tyrosine kinase receptor EGFR firstly by shedding most of its ligands, including AREG, HB-EGF, TNF-[alpha], EPGN (epigen), and EREG (epiregulin) [18], resulting in activation of EGFR.
Cell proliferation was also deregulated, and we found modulation of several transcripts including BTG family, member 2, BTG2, epiregulin, EREG, proline-rich coiled-coil 2C (PRRC2), phosphatase, tensin homolog pseudogene 1 (PTENP1), and amyloid beta (A4) precursor-like protein 2 (APLP2).
According to Missiaglia and colleagues [28], microsatellite instable-high (MSI) and BRAF mutation were predominate among proximal (right-sided) tumours, while distal cancers (left-sided) were characterised by chromosome instable, high expression of epiregulin, and human epidermal growth factor receptor 2 (HER2) amplification [24, 29, 30].
The LH stimulation induces a transient sequential expression of epidermal growth factors such as amphiregulin, epiregulin and betacellulin.
For example, the following genes exhibited statistically significant (P<05) modulation early in Zone I and late in Zone II: CDH5, PECAM-1, SERPINF1, TGFBR1, Endothelial cell growth factor-1 (Ecgfl), Endothelial PAS domain protein-1 (Epasl), Epiregulin (Ereg), Interleukin 12a (1112a), Integrin aV (Itgav), Nudix-type motif 6n (Nudt6), and Tumor necrosis factor ligand superfamily member-12 (Tnfsfl2).
The reported number of ErbB ligands increased to 11, namely, amphiregulin (AR), betacellulin (BCT), epidermal growth factor (EGF), epigen (EPG), epiregulin (EPR), heparin-binding EGF (HB-EGF), transforming growth factor alpha (TGF[alpha]), neuregulin- (NRG-) 1 to neuregulin-4 [5, 7, 38].
Brady et al., "Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival," Molecular Cancer, vol.
Epiregulin belongs to the epidermal growth factor (EGF) family and is produced as a result of activation of nuclear factor jB pathway(NF-jB) which is stimulated by TLR4 (Figure 3).
On the other hand, proliferative or synthetic SMCs show altered protein expression including increased expression of low-molecular weight caldesmon (l-caldesmon), c-fos, Egr-1, epiregulin, and SMemb MHC (Sobue et al.