forms demonstrated growth inhibition higher than that observed with benznidazole, (23) and activity against Leishmania donovani was observed, with considerable reduction in parasitic burden and spleen weight in vivo.
and that filaments roughly 11 nm in diameter connected the kDNA to the basal body (Figure 5(a)).
Flavonoids also inhibit the protein kinase, affecting the cellular proliferation, including that in epimastigote
and amastigote forms of T.
(Asteraceae, Compositae) against epimastigote
and amastigote forms.
Trypanosomatides occur in different morphological forms in its life cycle viz amastigote (leishmanial), promastigote (leptomonad), epimastigote
(crithidial), trypomastigote (trypanosomal) and opisthomastigote (herpetomonad).
Thus, the aim of this study was to investigate the antitrypanosomal activity of gallic acid and its esters against epimastigote
forms of Trypanosoma cruzi.
Inhibitory Effects on T cruzi Epimastigote
The standard curve for the absolute quantification was generated by a 1:10 serial dilution of DNA extracted from the Colombian strain epimastigote
culture stocks, ranging from [10.sup.6] to 10 parasite equivalents.
The present study evaluated the inhibitory effect of benznidazole on the growth of epimastigote
forms of T.
forms of the flagellate were maintained at 28[degrees]C in BHI medium supplemented with 10% (v [v.sup.-1]) heat-inactivated fetal bovine serum and 0.2% (v [v.sup.-1]) rabbit hemoglobin, pH 7.3 (growth medium).