Whereas current forensic and diagnostic screening technologies only detect the immediate presence of contaminants, the envisioned ECHO technology would read someones epigenome
from a biological sample even when other physical evidence has been erased.
Our results are relevant to understanding how arsenic impacts the epigenome
and how alteration of the epigenome
may be a mechanism involved in arsenic toxicity.
The placental epigenome
also responded to maternal stress according to gender; male offspring showed "maladaptive inflammatory and behavioral responses to stress as adults."
Nevertheless, the risk of diabetes in sib-pairs, one born to a diabetic and the other to a nondiabetic pregnancy, suggests that fetal programming occurs to some extent independently of genetic inheritance (49), possibly at the level of the epigenome
Liang, "Contributions of DNA methylation aberrancies in shaping the cancer epigenome
," Translational Cancer Research, vol.
Starting from the epigenome
editing, the first part of the article discussed the rewriting of the epigenetic markers at the given loci in the genome to uncover the effects caused by the targeted rewriting.
With more and more data available for pathogens and their hosts at genome, transcriptome, proteome, methylome, and epigenome
levels, computational modelling, big data analysis, and systems biology have become more and more important in revealing the biological mechanisms underlying these data, unraveling the secrets behind pathogen evolution, infection, and pathogen-host interactions.
7, researchers from the Salk Institute demonstrated they could use a CRISPR-based tool in mice to edit the epigenome
, the chemicals that dictate the functions of a genome, and change the behavior and function of the animal.
This is the first study to show in humans that the simple act of touching, early in life, has deeply-rooted and potentially lifelong consequences on the epigenome
- biochemical changes that affect gene expression.
The biology of the genome and epigenome
are relatively new fields.
Seed's approach is based on the science of epigenetics, which examines external or environmental factors such as aging, smoking, obesity, exercise, and environmental exposure, that can cause changes to the layer on top of the DNA known as the epigenome
Articles collecting significant developments in cancer research in the past year cover such topics as regulation and dysregulation of chromosome structure in cancer; histone mutations in cancer; and SWI/SNF complexes: guardians of the epigenome
. Other issues discussed include deregulation and therapeutic potential of the hippo pathway in cancer; circadian clock's cancer connections; lineage plasticity in cancer progression and treatment; the impact of the gut microbiome on colorectal cancer; oncolytic herpes simplex viruses as a paradigm for the treatment of cancer; nutrient sensing in cancer; and senescence and the hallmarks of cancer.