epidermal growth factor receptor


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epidermal growth factor receptor (EGFR),

[MIM*131550]
receptor often upregulated in epithelial tumors.

EGFR

A gene on chromosome 7p12 that encodes epidermal growth factor, a transmembrane glycoprotein of the protein kinase superfamily, which is a receptor for members of the epidermal growth factor family. Binding of the protein to a ligand induces receptor dimerisation and tyrosine autophosphorylation and leads to cell proliferation.

Molecular pathology
EGFR mutations are associated with lung cancer.

ep·i·der·mal growth fac·tor re·cep·tor

(EGFR) (ep'i-dĕr'măl grōth fak'tŏr rĕ-sep'tŏr)
Receptor often upregulated in epithelial tumors.
References in periodicals archive ?
Risk of high-grade skin rash in cancer patients treated with cetuximab--an antibody against epidermal growth factor receptor: systemic review and metaanalysis.
(5.) Wolff AC, Hammond MEH, Schwartz JN, et al: American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer.
The "triple negative" invasive breast carcinoma are tumors negative for Estrogen receptor (ER), Progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) oncoprotein analysis.
Radiation-induced release of transforming growth factor a activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death.
(2006) EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib.
Elevated expression of epidermal growth factor receptors mediated by Retinoic acid in human lung cancer cells.
Lou et al., "Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor al' Cell, vol.
About 75%-80% of lung cancers are non-small cell lung cancers.1-3 Erlotinib and Gefitinib is an inhibitor of human epidermal growth factor receptor-1 (HER-1) and (or) epidermal growth factor receptor tyrosine kinase (EGFR-TK).
Under the deal, RXi Pharma will issue 4.8m of its common shares to Apthera and may also provide contingent payments based on milestones related to the targeta[euro](tm)s NeuVax product candidate, a peptide-based immunotherapy for low-to-intermediate HER2+ (human epidermal growth factor receptor 2) breast cancer.
The drugmaker said that the European Commission had granted marketing authorization for its use in treating adults with locally advanced or metastatic non-small cell lung cancer, whose tumors have a mutation called epidermal growth factor receptor (EGFR).
Most conventional chemotherapy is believed to act through inhibition of highly proliferative cells via a variety of methods and in human epidermal growth factor receptor 2 (HER2)-positive breast cancer, biological agents target the enhanced growth properties of these cells.
Because these drugs often are prescribed concurrently with radiation therapy, it is important for radiation therapists to be able to recognize different types of epidermal growth factor receptor (EGFR) drugs and evaluate any side effects patients might experience during treatment.

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