epidermal growth factor


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ep·i·der·mal growth fac·tor (EGF),

[MIM*131530]
a heat-stable antigenic protein isolated from the submaxillary glands of male mice; when injected into newborn animals, it accelerates eyelid opening and tooth eruption, stimulates epidermal growth and keratinization, and, in larger doses, inhibits body growth and hair development and produces fatty livers.

EGF

A gene on chromosome 4q25 that encodes epidermal growth factor, a potent mitogen that plays a key role in the growth, proliferation and differentiation of numerous cell types; it acts by binding the high-affinity cell surface receptor, epidermal growth factor receptor.

Molecular pathology
Defects in EGF cause hypomagnesaemia type 4; EGF dysregulation is linked to the growth and progression of certain cancers.
References in periodicals archive ?
Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme.
Specificity of epidermal growth factor action on maturation of the murine oocytes and cumulus oophorus in vitro.
Cetuximab: an epidermal growth factor receptor monoclonal antibody for the treatment of colorectal cancer.
Trastuzumab is a monoclonal antibody which targets tumors that over-express the HER2 protein, an epidermal growth factor. The over-expression of HER2 occurs in 25 to 30% of persons with breast cancer (Slamon et al., 2001).
Epidermal growth factor (EGF) also promotes collagen synthesis, so the investigators thought it might help.
Elevated expression of epidermal growth factor receptors mediated by Retinoic acid in human lung cancer cells.
Gefitinib is a targeted cancer therapy that blocks a tyrosine kinase enzyme to treat non-small cell lung cancers caused by mutations in the epidermal growth factor receptor.
The epidermal growth factor (EGF) binds to the part of the EGFR protein that sits on the outside of the cell.4 Binding leads to activation of the EGFR protein which triggers a complex signalling cascade inside the cell that leads to events including accelerated cell growth and division and development of metastases (tumour growth and spread to other parts of the body).5,6 Some NSCLC tumours have activating mutations in the EGFR gene, changing the structure of the EGFR proteins such that they have increased activity.
Very recently, overexpression of human epidermal growth factor 2 (HER2) in patients whose breast cancers have amplified HER2 gene, has been found to predict for improvements in survival when treated with the anti-HER2 antibody trastuzumab in both the metastatic and adjuvant settings.
Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity.
Tumor cells dosed with THC also showed a reduction in epidermal growth factor receptor, or EGFR, which means the substance may be acting in ways similar to Erbitux and Vectibix, which block the protein, said the team from Harvard University's division of experimental medicine.

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