"I would also love to see epicutaneous
immunotherapy looked at in very young children," he added.
The thin-layer rapid-use epicutaneous
(T.R.U.E.) Test, distributed by Allerderm Laboratories, contains 23 antigens responsible for many cases of allergic contact dermatitis and is the only set of antigens currently approved by the Food and Drug Administration, said Dr.
In a sensitization-challenge treatment paradigm, epicutaneous
beryllium increased murine ear thickness following chemical challenge.
Viaskin Peanut is the company's lead product candidate, which is based on epicutaneous
immunotherapy, a proprietary technology platform that delivers biologically active compounds to the immune system through the skin.
In line with these findings, prophylactic, epicutaneous
treatment with R848 and the major birch pollen allergen Bet v 1 inhibited the production of biologically active Bet v 1-specific IgE antibodies, suppressed lung inflammation, and reduced AHR compared to Bet v 1 applied alone .
If the etiology isn't apparent, epicutaneous
patch testing may help determine whether allergic contact dermatitis is the culprit.
A thin-layer rapid-use epicutaneous
(TRUE) test revealed an allergy to nickel.
Classification of allergy among subjects was based on the presence or absence of positive allergen reactivity as assessed using epicutaneous
skin prick tests (SPTs) for house dust mites, cat, and various pollens and molds common to the study area (12).
DBV Technologies, the Geneva University Hospitals and BioNet-Asia presented new data from a Phase I study evaluating the safety and immunogenicity of boosting young adults against pertussis toxin with an investigational epicutaneous
patch containing recombinant PT.
On the other hand, it was recently demonstrated in LC ablation models that LCs could initiate epicutaneous
sensitization by OVA-specific IgE and thereby induce a Th2 response .