EFNB3

(redirected from ephrin-B3)

EFNB3

A gene on chromosome 17p13.1 that encodes ephrin-B3, a cell surface GPI-bound ligand for the Eph family of tyrosine kinase receptors, which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNB3 is crucial for the development and maintenance of the brain—especially of the forebrain; it binds to, and induces the collapse of, commissural axons/growth cones, and it may play a role in the orientation of longitudinally projecting axons. It is highly expressed in brain and interacts with GRIP1 and GRIP2.
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One, a protein called ephrin-B3, holds axons back, Stephen Strittmatter of Yale School of Medicine and colleagues reported in the March 27 Proceedings of the National Academy of Sciences.
For EphA7, EphB2, EphB4, EphB6, ephrin-B1, ephrin-B2, and ephrin-B3, immunohistochemistry was established to visualize some conclusive patterns of tissue-specific expression.
The samples were then incubated overnight with the primary antibody dilution at 4[degrees]C [EphB2, 1:75; EphB4, 1:75; EphB6, 1:150; EphA7, 1:100; ephrin-B2,1:75 (Santa Cruz Biotechnology); ephrinB1, 1:15; ephrin-B3, 1:25 (Zymed)].