EFNA3

(redirected from ephrin-A3)

EFNA3

A gene on chromosome 1q21-q22 that encodes ephrin-A3, a cell surface GPI-bound ligand for the Eph family of tyrosine kinase receptors, which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. It interacts with and activates EPHA8.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
Di Stefano et al., "MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand ephrin-A3," The Journal of Biological Chemistry, vol.
Wu, "Dissecting the roles of ephrin-A3 in malignant peripheral nerve sheath tumor by TALENs," Oncology Reports, vol.
Binding of glial ephrin-A3 to neuronal EphA4 maintains normal spine morphology [76] while preventing the interaction results in unstable spines with disrupted shapes [53].
Interfering with EphA4 or ephrin-A3 induces growth of astrocytic processes in cell culture [52].
Ephrin-A3 and -B3 were preferentially expressed in the brain, whereas ephrin-A2 and -A4 expression was highest in the colon.
Ephrin-A3 mRNA expression was up-regulated 26-fold in squamous cell lung carcinoma.
The interaction between ephrin-A3 and EphA4, which are expressed by astrocytes and dendritic spines of neurons, respectively, is involved in decreasing levels of GLAST and glutamate transporter 1 (GLT-1) for proper synapsing to occur [115-118].
Pasqualea, "Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport," Proceedings of the National Academy of Sciences of the United States of America, vol.