EFNA2

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EFNA2

A gene on chromosome 19p13.3 that encodes ephrin-A2, a cell surface GPI-bound ligand for the Eph family of tyrosine kinase receptors, which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA2, with the EPHA2 receptor, may play a role in bone remodelling by regulating osteoclastogenesis and osteoblastogenesis. It binds to EPHA3, EPHA4 and EPHA5; it interacts with and activates EPHA8.
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For the calibration curves for ephrin-A2 and EphA8, Human Reference RNA was pooled 1:1 with RNA from fetal human brain (Clontech).
Interestingly, except for EphA8 and ephrin-A2, all members of the family were expressed in all investigated healthy tissues, but the relative amounts of the transcripts varied considerably.
Ephrin-A3 and -B3 were preferentially expressed in the brain, whereas ephrin-A2 and -A4 expression was highest in the colon.